Hexadecahydro-1h-cyclopenta[a]phenanthrene derivatives useful in treating pain and inflammation

A compound of formula (I):

• wherein:
• is an optionally substituted fused pyrazolyl, oxazolyl, thiazolyl, thiadiazolyl, pyrazinyl or pyrimidinyl;
• R1 is hydrogen or —OR6;
• R2 is —OR6 or —N(R7)2;
• R3 is —OR6 or —N(R7)2;
• R4a and R4b together form alkylidene;
• R5 is alkyl or a direct bond to the carbon at C14;
• each R6 is independently selected from hydrogen or alkyl;
• each R7 is independently selected from hydrogen or alkyl;
• and
• R8 is direct bond or a straight or branched alkylene chain;
• or a stereoisomer, enantiomer or tautomer thereof or mixtures thereof, or a pharmaceutically acceptable salt or solvate thereof.