Akt3 modulators

A compound of Formula Ia, Ib, or Ic,

• or a pharmaceutically acceptable salt thereof;
• wherein:
• is
• each occurrence of X1, X2, X3, X4, X5, X6, X7, X8, and X9 are independently CR1 or N;
• R1 is selected from the group consisting of H, D, halogen, (C1-C6)alkyl, (C1-C6)haloalkyl, (C2-C6)alkenyl, (C2-C6)haloalkenyl, (C2-C6)alkynyl, (C2-C6)haloalkynyl, (C3-C7)cycloalkyl, (C4-C10)bicycloalkyl, (C3-C7)heterocycloalkyl, (C4-C10)heterobicycloalkyl, (C4-C10)heterospiroalkyl, halogenated (C3-C7)heterocycloalkyl, aryl, heteroaryl, —ORa, —SRa, —N(Ra)2, —CORa, —CO2Ra, CON(Ra)2, —CN, —NC, NO2, N3, —SO2Ra, —SO2N(Ra)2, —N(Ra)SO2Ra,
• and a partially saturated bicyclic heteroaryl optionally substituted by one or more (C1-C6)alkyl, halogenated (C1-C6)alkyl, —SO2Ra, or —SO2N(Ra)2;
• wherein the (C3-C7)cycloalkyl, (C4-C10)bicycloalkyl, (C3-C7)heterocycloalkyl, (C4-C10)heterobicycloalkyl, (C4-C10)heterospiroalkyl, aryl, and heteroaryl of R1 are each optionally substituted by one or more (C1-C6)alkyl, halogenated (C1-C6)alkyl, halogen, —ORa, —CN, or —N(Ra)2;
• n is an integer from 0-4 where valence permits;
• Q is C(Ra)2, O, NRa, N(C═O)Ra, or NSO2Ra;
• Y1, Y2, Y3, Y4 and Y5 are each independently N or CR2 where valance permits;
• R2 is selected from the group consisting of H, D, halogen, (C1-C6)alkyl, (C1-C6)haloalkyl, (C2-C6)alkenyl, (C2-C6)haloalkenyl, (C2-C6)alkynyl, (C2-C6)haloalkynyl, (C3-C7)cycloalkyl, (C4-C10)bicycloalkyl, (C3-C7)heterocycloalkyl, (C4-C10)heterobicycloalkyl, (C4-C10)heterospiroalkyl, halogenated (C3-C7)heterocycloalkyl, aryl, heteroaryl, —ORa, —SRa, —N(Ra)2, —CORa, —CO2Ra, CON(Ra)2, —CN, —NC, NO2, N3, —SO2Ra, —SO2N(Ra)2, —N(Ra)SO2Ra,
• -E-G- is —(C═O)NRx—, —NRx(C═O)—, —N(Rx)(C═O)N(Rx)—, —O(C═O)N(Rx)—,
• —N(Rx)(C═O)O—, —SO2NRx—, —NRxSO2—, or
• wherein
• each occurrence of Rx is independently H, (C1-C6)alkyl, (C3-C7)cycloalkyl, aryl, or heteroaryl;
• or wherein Rx and Y2, Rx and Y3, Rx and Z1, or Rx and Z4 taken together form an optionally substituted 5-6-membered heterocycle;
• W1, W2, W3, W4, and W5 are each independently CR6, N, or NR6 where valence permits;
• each occurrence of R6 is independently selected from the group consisting of H, halogen, (C1-C6)alkyl, and (C1-C6)haloalkyl;
• each occurrence of T is independently O, N, NRa, N(C═O)Ra, NC(Rb)2OP(═O)(ORb)2, or NSO2Ra where valance permits;
• each occurrence of U is independently O, N, NRa, N(C═O)Ra, NC(Rb)2OP(═O)(ORb)2, or NSO2Ra where valance permits;
• each occurrence of Rb is independently H or (C1-C6)alkyl;
• Z1, Z2, Z3, Z4 and Z5 are each independently N or CR3 where valance permits;
• R3 is selected from the group consisting of H, D, halogen, (C1-C6)alkyl, (C1-C6)haloalkyl, (C2-C6)alkenyl, (C2-C6)haloalkenyl, (C2-C6)alkynyl, (C2-C6)haloalkynyl, (C3-C7)cycloalkyl, (C4-C10)bicycloalkyl, (C3-C7)heterocycloalkyl, (C4-C10)heterobicycloalkyl, (C4-C10)heterospiroalkyl, halogenated (C3-C7)heterocycloalkyl, aryl, heteroaryl, —ORa, —SRa, —N(Ra)2, —CORa, —CO2Ra, CON(Ra)2, —CN, —NC, NO2, N3, —SO2Ra, —SO2N(Ra)2, —N(Ra)SO2Ra,
• V is absent, C(Ra)2, NRa, N(C═O)Ra, NSO2Ra or O;
• R4 is selected from the group consisting of (C1-C6)alkyl, (C3-C7)cycloalkyl, (C4-C10)bicycloalkyl, (C3-C7)heterocycloalkyl, (C4-C10)heterobicycloalkyl, (C4-C10)heterospiroalkyl, aryl, and heteroaryl, each optionally substituted with one or more R5;
• or alternatively V and R4 taken together form a (C3-C7)heterocycloalkyl or (C4-C10)heterospiroalkyl;
• each occurrence of R5 is independently selected from the group consisting of H, D, halogen, (C1-C6)alkyl, (C1-C6)haloalkyl, (C2-C6)alkenyl, (C2-C6)haloalkenyl, (C2-C6)alkynyl, (C2-C6)haloalkynyl, (C3-C7)cycloalkyl, (C4-C10)bicycloalkyl, (C3-C7)heterocycloalkyl, (C4-C10)heterobicycloalkyl, (C4-C10)heterospiroalkyl, halogenated (C3-C7)heterocycloalkyl, aryl, heteroaryl, —ORa, —SRa, —N(Ra)2, —CORa, —CO2Ra, CON(Ra)2, —CN, —NC, NO2, N3, —SO2Ra, —SO2N(Ra)2, —N(Ra)SO2Ra, N(Ra)CORa,
• each occurrence of Ra is independently H, (C1-C6)alkyl, (C2-C6)alkenyl, (C3-C7)cycloalkyl, aryl, or heteroaryl, or two Ra taken together form a 4-6-membered ring optionally substituted with halogen or (C1-C6)alkyl;
• with the proviso that the compound is not