Difluoromethyl iodo compounds and methods
AssigneeRecurium IP Holdings, LLC
InventorsAditya Krishnan Unni, Joseph Robert Pinchman, Peter Qinhua Huang, Kevin Duane Bunker
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Abstract
The present application is related to an improved process for synthesising 1-(difluoromethyl)-3-iodobicyclo[1.1.1]pentane from difluoromethyl iodide and [1.1.1]propellane. Difluoromethyl iodide is made by reacting an iodide salt with chlorodifluoroacetic acid in the presence of a solvent such as sulfolane and an inorganic base, [1.1.1]propellane is synthesised by reacting 1,1-dibromo-2,2-cis(chloromethyl)cyclopropane with a reagent such as magnesium, methyllithium or phenyllithium.
Claims24
A process of making difluoromethyl iodide (CHF2I), comprising reacting an iodide salt with chlorodifluoroacetic acid under reaction conditions that are selected to produce the difluoromethyl iodide, wherein the reaction conditions comprise:
- an effective amount of a reaction solvent;
- an effective amount of the iodide salt dispersed in the reaction solvent;
- and
- an effective amount of an inorganic base dispersed in the reaction solvent.
A process for making 1-(difluoromethyl)-3-iodobicyclo[1.1.1]pentane, comprising intermixing difluoromethyl iodide (CHF2I) with [1.1.1]propellane under reaction conditions that are selected to produce the 1-(difluoromethyl)-3-iodobicyclo[1.1.1]pentane.
24-32. (canceled)
Dependencies are inferred from the claim text.