Biodegradable, Antioxidant, Thermally Responsive Injectable Hydrogel and Uses Therefor
AssigneeUniversity of Pittsburgh—Of the Commonwealth System of Higher Education
InventorsWilliam R. Wagner, Yasumoto Matsumura, Murugesan Velayutham, Yang Zhu
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Abstract
Provided herein are antioxidant, thermally-responsive polymeric compositions and methods of making and using the compositions, e.g., for treatment of ischemia reperfusion injury or radiation exposure.
Claims20
A thermal responsive copolymer composition, comprising N-isopropylacrylamide (NIPAAm) residues, vinyl pyrrolidone residues, polyester acrylate macromer residues, and acrylate residues comprising a reactive group, the copolymer having a transition temperature between 10° C. and 35° C., above which temperature, the polymer composition transitions from an aqueous-miscible state to a higher viscosity partially-miscible or immiscible state in an aqueous solution.
A method of treating ischemia or an ischemia reperfusion injury at a site in a patient, comprising administering to the patient at the site of the ischemia or ischemia reperfusion injury a thermal responsive copolymer composition, comprising n-isopropylacrylamide (NIPAAm) residues, vinyl pyrrolidone residues, polyester acrylate macromer residues, and antioxidant acrylate residues, the copolymer having a transition temperature between 10° C. and 35° C., above which temperature, the polymer composition transitions from an aqueous-miscible state to a higher viscosity partially-miscible or immiscible state in an aqueous solution.
Dependencies are inferred from the claim text.