Host-targeted pan-respiratory antiviral small molecule therapeutics

A compound of Formula (I):

• or pharmaceutically acceptable salts, hydrates or solvates thereof, wherein:
• R1 and R2 are independently alkyl, alkenyl, cycloalkyl or cycloalkenyl;
• R3 is —H or alkyl;
• a is 1, 2 or 3;
• R4 is —H, halo, alkyl, —OR7;
• R5 is —H, halo, alkyl, substituted alkyl,
• —C(O)NR76R77, —NR78R79, —NHC(O)R80, —OR11;
• b is 0, 1, 2 or 3,
• R6 is —H, alkyl,
• c is 1, 2 or 3;
• X is
• substituted aryl, heteroaryl, substituted heteroaryl.
• R8 is —H, —C(O)NR16R17, —CH2OC(O)NR18R19, —NR20R21, —CH2NR22R23 or —SO2R24R25;
• R9 is —H, —C(O)NR26R27, —CH2OC(O)NR28R29, —NR30R31, —CH2NR32R33 or —SO2R34R35;
• R10 is —H, —C(O)NR36R37, —CH2OC(O)NR38R39, —NR40R41, —CH2NR42R43 or —SO2R44R45;
• R12 is —H, —C(O)NR46R47, —CH2OC(O)NR48R49, —NR5OR51, —CH2NR52R53 or —SO2R54R55;
• R13 is —H, substituted alkyl, —C(O)NR56R57, —CH2OC(O)NR58R59, —NR60R61 or —CH2NR62R63 or —SO2R64R65;
• R14 is —H, —C(O)N66R67, —CH2OC(O)NR68R69, —NR70R71 or —CH2NR72R73 or —SO2R74R75;
• R7, R11 and R15 are independently alkyl, substituted alkyl alkenyl, substituted alkenyl, heteroalkyl, substituted heteroalkyl, heteroalkenyl or substituted heteroalkenyl.
• R16 and R17 together with the atoms to which they are attached form a heterocyclic or substituted heterocyclic ring;
• R18 and R19 together with the atoms to which they are attached form a heterocyclic or substituted heterocyclic ring;
• R20 and R21 together with the atoms to which they are attached form a heterocyclic or substituted heterocyclic ring;
• R22 and R23 together with the atoms to which they are attached form a heterocyclic or substituted heterocyclic ring;
• R24 and R25 together with the atoms to which they are attached form a heterocyclic or substituted heterocyclic ring;
• R26 and R27 together with the atoms to which they are attached form a heterocyclic or substituted heterocyclic ring;
• R28 and R29 together with the atoms to which they are attached form a heterocyclic or substituted heterocyclic ring;
• R30 and R31 together with the atoms to which they are attached form a heterocyclic or substituted heterocyclic ring;
• R32 and R33 together with the atoms to which they are attached form a heterocyclic or substituted heterocyclic ring;
• R34 and R35 together with the atoms to which they are attached form a heterocyclic or substituted heterocyclic ring;
• R36 and R37 together with the atoms to which they are attached form a heterocyclic or substituted heterocyclic ring;
• R38 and R39 together with the atoms to which they are attached form a heterocyclic or substituted heterocyclic ring;
• R40 and R41 together with the atoms to which they are attached form a heterocyclic or substituted heterocyclic ring;
• R42 and R43 together with the atoms to which they are attached form a heterocyclic or substituted heterocyclic ring;
• R44 and R45 together with the atoms to which they are attached form a heterocyclic or substituted heterocyclic ring;
• R46 and R47 together with the atoms to which they are attached form a heterocyclic or substituted heterocyclic ring;
• R48 and R49 together with the atoms to which they are attached form a heterocyclic or substituted heterocyclic ring;
• R50 and R51 together with the atoms to which they are attached form a heterocyclic or substituted heterocyclic ring;
• R52 and R53 together with the atoms to which they are attached form a heterocyclic or substituted heterocyclic ring;
• R54 and R15 together with the atoms to which they are attached form a heterocyclic or substituted heterocyclic ring;
• R56 and R57 together with the atoms to which they are attached form a heterocyclic or substituted heterocyclic ring;
• R58 and R59 together with the atoms to which they are attached form a heterocyclic or substituted heterocyclic ring;
• R60 and R61 together with the atoms to which they are attached form a heterocyclic or substituted heterocyclic ring;
• R62 and R63 together with the atoms to which they are attached form a heterocyclic or substituted heterocyclic ring;
• R64 and R65 together with the atoms to which they are attached form a heterocyclic or substituted heterocyclic ring;
• R66 and R67 together with the atoms to which they are attached form a heterocyclic or substituted heterocyclic ring;
• R68 and R69 together with the atoms to which they are attached form a heterocyclic or substituted heterocyclic ring;
• R70 and R71 together with the atoms to which they are attached form a heterocyclic or substituted heterocyclic ring;
• R72 and R73 together with the atoms to which they are attached form a heterocyclic or substituted heterocyclic ring;
• R74 and R75 together with the atoms to which they are attached form a heterocyclic or substituted heterocyclic ring;
• R76, R77, R78, or R79 are independently alkyl, substituted alkyl alkenyl, substituted alkenyl, heteroalkyl, substituted heteroalkyl, heteroalkenyl or substituted heteroalkenyl or alternatively, R76 and R77 together with the atoms to which they are attached form a heterocyclic or substituted heterocyclic ring or R78, or R79 together with the atoms to which they are attached form a heterocyclic or substituted heterocyclic ring;
• R80 is alkyl, substituted alkyl, alkenyl, substituted alkenyl, aryl, substituted aryl, heteroalkyl, substituted heteroalkyl, heteroalkenyl, substituted heteroalkenyl, aryl or substituted aryl;
• provided that at least one of R5 or R6 is not —H;
• provided that at least one of R8-R10 is not —H;
• and
• provided that at least one of R12-R14 is not —H.