Back to results
US 2023/0146665 A1Published application
Il-18-fc fusion proteins
AssigneeXencor, Inc.
InventorsAlex Nisthal, John Desjarlais, Gregory Moore, Sung-Hyung Lee
Life of this patent
Estimating the term…
Loading patent…
Loading patent…
AssigneeXencor, Inc.
InventorsAlex Nisthal, John Desjarlais, Gregory Moore, Sung-Hyung Lee
Estimating the term…
Provided herein are IL18-Fc fusion proteins that include an empty-Fc domain and an IL18 protein connected to another Fc domain. Also provided herein are additional are IL18-Fc fusion proteins such as IL18 x Fab-Fc fusion proteins that include a first monomer containing an IL18 protein connected to a first Fc domain, a second monomer containing a variable heavy chain connected to a second Fc domain, and a variable light chain, such that the variable heavy and light chains form an empty Fab. Various variant IL18 proteins with modifications to reduce heterogeneity and/or reduce affinity/potency and/or improve stability and/or improve production yield are also described.
A composition comprising a variant human IL18 protein, wherein the variant IL18 protein comprises a modification at one or more amino acid positions selected from the group consisting of Y1, E6, S7, K8, S10, V11, N14, L15, D17, Q18, D23, R27, P28, L29, E31, M33, T34, D35, S36, D37, C38, R39, D40, N41, R44, I46, I49, S50, M51, K53, D54, S55, Q56, P57, M60, A61, V62, T63, S65, K67, C68, E69, I71, C76, E77, I80, I81, N87, P88, D90, K93, T95, K96, S97, Q103, H109, D110, N111, M113, S119, A126, C127, D132, L136, L138, K139, E141, L144, D146, R147, I149, M150, N155, E156, and D157, as compared to wildtype human IL18.
-15. (canceled)
A monovalent Fc fusion protein comprising:
-33. (canceled)
A monovalent Fc fusion protein comprising:
-38. (canceled)
A Fab-Fc fusion protein comprising:
-56. (canceled)
A Fab-Fc fusion protein comprising:
-65. (canceled)
Dependencies are inferred from the claim text.