Substituted Pyrimidines and Uses Thereof

A compound of Formula (I):

• wherein:
• R1a and R1b taken together with the nitrogen to which they are attached form:
• wherein X and Y are independently N or CRa;
• wherein Ra is H or C1-4alkyl;
• and
• Rb is phenyl, monocyclic cycloalkyl, monocyclic heterocyclyl, monocyclic heterocycloalkyl, or monocyclic heteroaryl, each optionally substituted with one, two, or three Rd substituents;
• or R1a is H or C1-4alkyl;
• and R1b is a heteroaryl optionally substituted with Rc;
• wherein Rc is C1-4alkyl, phenyl, —C1-4alkyl-phenyl, monocyclic cycloalkyl, —C1-4alkyl-(monocyclic cycloalkyl), monocyclic heterocyclyl, monocyclic heterocycloalkyl, monocyclic heteroaryl, or —C1-4alkyl-(monocyclic heteroaryl), wherein each alkyl, phenyl, cycloalkyl, heterocyclyl, heterocycloalkyl or heteroaryl is optionally substituted with one, two, or three Rd substituents;
• wherein each Rd substituent is independently C1-4alkyl, C1-4alkenyl, C1-4alkynyl, —O—C1-4alkyl, halo, cyano, nitro, azido, C1-4haloalkyl, —O—C1-4-haloalkyl, —NRgRh, —NRgC(═O)Rh, —NRgC(═O)NRgRh, —NRgC(═O)ORh, ═NORg, —NRgS(═O)1-2Rh, —NRgS(═O)1-2NRgRh, ═NSO2Rg, —C(═O)Rg, —C(═O)ORg, —OC(═O)ORg, —OC(═O)Rg, —C(═O)NRgRh, —OC(═O)NRgRh, —ORg—, —SRg, —S(═O)Rg, —S(═O)2Rg, —OS(═O)1-2Rg, —S(═O)1-2ORg, or —S(═O)1-2NRgRh;
• wherein Rg and Rh are each independently H or C1-4alkyl;
• each of R2 and R3 is independently chosen from H, C1-4alkyl, cycloalkyl, C1-4alkylcycloalkyl, heterocyclyl, heterocycloalkyl, and heteroaryl optionally substituted with one, two, or three Rj substituents;
• or R2 and R3 taken together with the nitrogen to which they are attached form a heterocyclyl, optionally substituted with one, two, three, or four Rj substituents, or further wherein any of the hydrogens bonded to carbon atoms are optionally replaced by deuterium;
• wherein each Rj substituent is independently C1-4alkyl, —OH, oxo, —NRkRl, halo, C1-4haloalkyl, —O—C1-4alkyl, or —O—C1-4-haloalkyl;
• where Rk and Rl are each independently H or C1-4alkyl;
• R4 is H, halo, —C(O)OH, C1-4alkylNRxRy, or —C(O)NRxRy, or is a cycloalkyl, heterocyclyl, heterocycloalkyl, phenyl or heteroaryl, wherein each cycloalkyl, heterocyclyl, heterocycloalkyl, phenyl or heteroaryl is optionally substituted with one, two, or three Rz substituents;
• wherein Rx is H or C1-4alkyl and Ry is H, C1-4alkyl, —O—C1-4alkyl, —SO2—Rr, C1-4alkyl-SO2—Rr monocyclic cycloalkyl, —C1-4alkyl(monocyclic cycloalkyl), monocyclic heterocyclyl, or monocyclic heterocycloalkyl, each optionally substituted with one, two, or three Ro substituents;
• or Rx and Ry taken together with the nitrogen to which they are attached form a monocyclic heterocyclyl, optionally substituted with C1-4alkyl or —OC1-4alkyl;
• and
• each Rz substituent is independently C1-4alkyl, halo, —NRpRq, —C(O)NRPRq, —OH, or —OC1-4alkyl, wherein each alkyl is optionally substituted with —NRmRn;
• wherein Rm and Rn are each independently H, C1-4alkyl, C(O)C1-2alkyl, C(O)C1-2haloalkyl, C(O)C1-2alkenyl, or Rm and Rn taken together with the nitrogen to which they are attached form a monocyclic heterocycloalkyl, optionally substituted with one or two Ro substituents;
• wherein each Ro substituent is independently C1-4alkyl, —OH, —OC1-4alkyl, halo, cyano, methylsulfonyl, —NRpRq, or —C(O)NRpRq;
• wherein Rp and Rq are each independently H, C1-4alkyl, C1-4alkylNH2, C1-4alkylNH(C1-4alkyl), or C1-4alkylN(C1-4alkyl)2;
• wherein each Rr is independently C1-4alkyl or NRpRq;
• and
• R5 is H, C1-4alkyl, halo, —OH, or —OC1-4alkyl;
• or a pharmaceutically acceptable salt or prodrug or prodrug thereof.