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US 2023/0145645 A1Published application
Enhanced detection and quantitation of biomolecules
AssigneePrognomIQ, Inc.
InventorsBruce Wilcox, Kavya Swaminathan, Preston B. Williams, Jared Deyarmin, Mi Yang
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Abstract
Described herein are methods for screening for a disease state. The method may include obtaining multiple data sets, and identifying the disease state based on a combination of the data sets. The data sets may include biomolecule measurements obtained by multiple methods, such as through the use of particles and reference biomolecules.
Claims20
A classification method, comprising:
- (a) obtaining a first data set comprising first measurements of biomolecules adsorbed to particles from a first biological sample of a subject;
- (b) obtaining a second data set comprising second measurements of the biomolecules of the first biological sample or of a second biological sample of the subject, wherein the second measurements comprise measurements of endogenous biomolecules normalized or adjusted based on measurements of internal standards of the biomolecules combined with the first biological sample or combined with the second biological sample, wherein the internal standards comprise a non-endogenous labeled version of the endogenous biomolecules, and wherein the second measurements are obtained with the first measurements or separately;
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- (c) applying a classifier to evaluate a biological state in the subject using a combination of features from the first data set and the second data set.
1 more element
A classification method, comprising:
- (a) obtaining a first data set comprising first measurements of biomolecules adsorbed to particles from a first biological sample of a subject;
- (b) obtaining a second data set comprising second measurements of the biomolecules of the first biological sample or of a second biological sample of the subject, wherein the second measurements comprise measurements of endogenous biomolecules normalized or adjusted based on measurements of internal standards of the biomolecules combined with the first biological sample or combined with the second biological sample, wherein the internal standards comprise a non-endogenous labeled version of the endogenous biomolecules, and wherein the second measurements are obtained with the first measurements or separately;
- (c) applying a first classifier to assign a first label corresponding to a biological state to the first data set;
- (d) applying a second classifier to assign a second label corresponding to the biological state to the second data set;
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- (e) combining the first label and the second label to obtain a combined label corresponding to the biological state.
3 more elements
Dependencies are inferred from the claim text.