Method of treatment of drug resistant hypertension

A method for determining stimulus protocols, the method comprising:

• receiving a physiological input value;
• calculating a pacing rate based on the physiological input value;
• determining a supra-threshold stimulus protocol to produce cardiac pacing and stimulation of one or both of local sympathetic tissue or parasympathetic tissues to modify the physiological input value, based on the pacing rate;
• and
• determining a sub-threshold stimulus protocol to produce feedback inhibition of a portion of an autonomic nervous system to modify the physiological input value, based on the pacing rate, wherein each of the supra-threshold stimulus protocol and the sub-threshold stimulus protocol comprises a respective composite amplitude of pacing stimulus, frequency of sub-pulses, duration of sub-pulses, and refractory period between a current pacing stimulus and a subsequent pacing stimulus.

A system for determining stimulus protocols, the system comprising:

• one or more pacing electrodes;
• an algorithmic module;
• a pacing module;
• at least one memory storing instructions;
• and
• at least one processor executing the instructions to perform operations, the operations comprising:
• receiving, at the algorithmic module, a physiological input value;
• calculating, at the algorithmic module, a pacing rate based on the physiological input value;
• determining, at the pacing module, a supra-threshold stimulus protocol to produce cardiac pacing and stimulation of one or both of local sympathetic tissue or parasympathetic tissues to modify the physiological input value, based on the pacing rate;
• and
• determining, at the pacing module, a sub-threshold stimulus protocol to produce feedback inhibition of a portion of an autonomic nervous system to modify the physiological input value, based on the pacing rate, wherein each of the supra-threshold stimulus protocol and the sub-threshold stimulus protocol comprises a respective composite amplitude of pacing stimulus, frequency of sub-pulses, duration of sub-pulses, and refractory period between a current pacing stimulus and a subsequent pacing stimulus.

A method for determining stimulus protocols, the method comprising:

• receiving a physiological input value;
• calculating a pacing rate based on the physiological input value;
• receiving one of an indication that a paced cardiac beat is indicated or that a paced cardiac beat is not indicated;
• determining, based on receiving the indication that the paced cardiac beat is indicated, a supra-threshold stimulus protocol to produce cardiac pacing and stimulation of one or both of local sympathetic tissue or parasympathetic tissues to modify the physiological input value, based on the pacing rate, wherein the supra-threshold stimulus protocol comprises a first composite amplitude of pacing stimulus, a first frequency of sub-pulses, a first duration of sub-pulses, and a first refractory period between a current pacing stimulus and a subsequent pacing stimulus;
• and
• determining, based on receiving the indication that the paced cardiac beat is indicated, a sub-threshold stimulus protocol to produce feedback inhibition of a portion of an autonomic nervous system to modify the physiological input value based on the pacing rate, wherein the sub-threshold stimulus protocol comprises a second composite amplitude of pacing stimulus, a second frequency of sub-pulses, a second duration of sub-pulses, and a second refractory period between a current pacing stimulus and a subsequent pacing stimulus.