Alpha-Ketobutyrate, 2-Hydroxybutyrate, and Alpha-Ketoglutarate for Stimulating Hair Growth

A method of stimulating new hair growth in a subject in need thereof, comprising:

• administering to the subject a composition comprising a therapeutically effective amount of a compound of Formula I:
• wherein
• R1 is hydrogen, halogen, —CHO, —OR7, —NR8R9, —COOR7, —CONR8R9, —SR10, substituted or unsubstituted alkyl, or substituted or unsubstituted heteroalkyl;
• R2 and R3 are each independently hydrogen, halogen, —CN, —CHO, —OR7, —NR8R9, —COOR7, —CONR8R9, —NO2, —SR10, substituted or unsubstituted alkyl, or substituted or unsubstituted heteroalkyl;
• or R2 and R3, together with the atom to which they are bound, form an oxo;
• R4, R5, and R6 are each independently hydrogen, halogen, —CN, —CHO, —OR7, —NR8R9, —COOR7, —CONR8R9, —NO2, —SR10, substituted or unsubstituted alkyl, or substituted or unsubstituted heteroalkyl;
• and
• R7, R8, R9, and R10 are each independently hydrogen, substituted or unsubstituted alkyl, substituted or unsubstituted heteroalkyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted heterocycloalkyl, substituted or unsubstituted aryl, or substituted or unsubstituted heteroaryl;
• or a salt thereof;
• and
• an excipient;
• and
• wherein the composition is administered to an area on the subject absent of hair to stimulate new hair growth.

A composition comprising a compound of Formula I:

• wherein
• R1 is hydrogen, halogen, —CHO, —OR7, —NR8R9, —COOR7, —CONR8R9, —SR10, substituted or unsubstituted alkyl, or substituted or unsubstituted heteroalkyl;
• R2 and R3 are each independently hydrogen, halogen, —CN, —CHO, —OR7, —NR8R9, —COOR7, —CONR8R9, —NO2, —SR10, substituted or unsubstituted alkyl, or substituted or unsubstituted heteroalkyl;
• or R2 and R3, together with the atom to which they are bound, form an oxo;
• R4, R5, and R6 are each independently hydrogen, halogen, —CN, —CHO, —OR7, —NR8R9, —COOR7, —CONR8R9, —NO2, —SR10, substituted or unsubstituted alkyl, or substituted or unsubstituted heteroalkyl;
• and
• R7, R8, R9, and R10 are each independently hydrogen, substituted or unsubstituted alkyl, substituted or unsubstituted heteroalkyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted heterocycloalkyl, substituted or unsubstituted aryl, or substituted or unsubstituted heteroaryl;
• or a salt thereof,
• and a pharmaceutically acceptable excipient and/or a tissue penetrating enhancer.