Back to results
US 2023/0144204 A1Published application
Fragments of hlya and uses thereof
AssigneeNumaferm GmbH
InventorChristian SCHWARZ
Life of this patent
Estimating the term…
Abstract
The present disclosure relates to the field of molecular biology, recombinant peptide, and protein expression and relates to amino acid sequences comprising hemolysin A (HlyA) fragments to improve the expression and secretion of a peptide or protein of interest.
Claims15
A polypeptide variant comprising a first amino acid sequence, wherein the first amino acid sequence comprises:
- (1) 30 to 202 amino acids in length;
- and
- (2) at least 80% sequence identity over its entire length with an amino acid sequence comprised in the amino acid sequence set forth in SEQ ID NO:1 (HlyA1), wherein the polypeptide variant does not include the full amino acid sequence as set forth in SEQ ID NO:1 and does not include the C-terminal amino acid motif TTSA (SEQ ID NO:27).
Dependencies are inferred from the claim text.