Loading patent…
OwnerXibao LIU, Yanling LI +6inventors
InventorsXibao LIU, Yanling LI, Jieru LIU, Stuart C. APFEL, Yuxiu MA, Xiaojuan WU, Yuqing WANG, Hanyu YANG
Estimating the term…
The present application provides application of butylphthalide or optical isomer, prodrug, deuterium, metabolite, and ring-opening product or ring-opening product salt thereof in the preparation of a drug for preventing, alleviating, or treating peripheral neuropathy, especially chemotherapy-induced peripheral neuropathy, and a use method of butylphthalide and a derivative thereof in preventing or treating peripheral neuropathy, especially chemotherapy-induced peripheral neuropathy. In vivo and in vitro studies show that the drug of the present invention can effectively prevent, alleviate, or treat peripheral neuropathy caused by chemotherapy drugs without affecting the tumor-inhibiting efficacy and pharmacokinetic properties of the chemotherapy drugs.
1-14. (canceled)
A method for preventing, relieving, or treating a drug-induced peripheral neuropathy, including administering to a subject in need thereof a therapeutically effective amount of butylphthalide or an optical isomer, a prodrug, a deuterated product, a metabolite, a ring-opening product, or a salt of the ring-opening product thereof.
A method for preventing, relieving, or treating a drug-induced peripheral neuropathy, including administering to a subject in need thereof a pharmaceutical composition comprising a therapeutically effective amount of butylphthalide or an optical isomer, a prodrug, a deuterated product, a metabolite, a ring-opening product, or a salt of the ring-opening product thereof, and a pharmaceutically acceptable excipient.
Dependencies are inferred from the claim text.