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US 2023/0143708 A1Published application
Antimicrobial organosilanes
AssigneeTopikos Pharmaceuticals, Inc.
InventorsGary Allred, Lanny Liebeskind, William R. Cast, Carl Hilliard
Life of this patent
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Abstract
Organosilicon quaternary ammonium compounds, their formulations, including powdered and solid formulations, and methods of use to treat infections in humans and animals.
Claims30
A quaternary ammonium compound of Formula:
- wherein
- a is 1, 2, 3, 4, 5, 6, 7 or 8;
- R1 is independently at each occurrence selected from C6-C22alkyl and C6-C22alkanoyl;
- R2, R3, R4, R22, R23, and R24 are independently at each occurrence selected from the group consisting of:
- each R21 is independently selected from C1-C22alkyl and C2-C22alkanoyl;
- R7 is independently at each occurrence selected from hydrogen, C1-C8alkyl, C1-C8hydroxyalkyl, and C1-C8 alkanoyl;
- R8 and R9 are independently at each occurrence selected from hydrogen, halogen, hydroxyl, N(R7)2, CH2OR7, CON(R7)2, COOR7, C(O)R7, C1-C8alkyl, C1-C8hydroxyalkyl, and C1-C8alkanoyl;
- X1 is NR17, CH2, CHOH, or C(O);
- X2 is C1-C3alkyl or C1-C3hydroxyalkyl;
- R16 is C1-C4alkyl;
- R17 is hydrogen, C1-C8hydroxyalkyl, or C1-C8alkanoyl;
- X− is an anion or is absent if the quaternary amine is balanced with an internal anion;
- and
- B+ is a cation.
11 more elements
Dependencies are inferred from the claim text.