Liquid preparations of amines and organic acids stabilized by salts
AssigneeTakeda Pharmaceutical Company Limited
InventorsMegumi Ikeda, Shohei Horiuchi, Tomomi Sato, Shinichiro Nakai, Kenichiro Kiyoshima
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Abstract
Provided are a liquid preparation wherein the pharmaceutically active ingredient is stabilized, and a stabilizing method therefor. A liquid preparation comprising a pharmaceutically active ingredient having a primary or secondary amino group (wherein the amino group does not constitute a part of the amide structure), an organic acid and a salt, which is substantially free of a reaction product of the pharmaceutically active ingredient and the organic acid.
Claims22
1-31. (canceled)
A method of stabilizing a liquid preparation, comprising adding a salt to a composition containing a pharmaceutically active ingredient having a primary or secondary amino group, wherein the amino group does not constitute a part of an amide structure, and an organic acid.
Dependencies are inferred from the claim text.