Novel imidazopyrazine derivatives

A compound of formula (I):

• or a pharmaceutically acceptable salt thereof, wherein:
• X is selected from a covalent bond, carbonyl, —(CH2)p—C(O)—NR4—, —NR4—C(O)—(CH2)s—, —(CH2)qSO2—, —SO2(CH2)q—, —NR5—S(O)2—, —S(O)2—NR5—, a group
• and a group
• wherein
• the asterisk indicates the point of attachment of R1 to X;
• and
• the wavy line indicates the point of attachment of X to the remainder of formula (I);
• R1 is selected from hydrogen, halogen, cyano, amino, hydroxy, (C1-C6-alkyl)2N—C(O)—C1-C6-alkyl, (C1-C6-alkyl)2N—C1-C6-alkoxy-C1-C6-alkyl, C1-C6-alkyl, halo-C1-C6-alkyl, cyano-C1-C6-alkyl, hydroxy-C1-C6-alkyl, amino-C1-C6-alkyl, C1-C6-alkyl-NH—C1-C6-alkyl, (C1-C6-alkyl)2N—C1-C6-alkyl, (C1-C6-alkyl)3N+—C1-C6-alkyl, C1-C6-alkyl-NH—, (C1-C6-alkyl)2N—, C1-C6-alkoxy, halo-C1-C6-alkoxy, amino-C1-C6-alkoxy, amino-C1-C6-alkoxy-C1-C6-alkyl, amino-(CH2CH2O)r—, C1-C6-alkyl-C(O)—NH—C1-C6-alkoxy, C1-C6-alkyl-NH—C(O)—, and a group
• and
• R2 is, at each occurrence, independently selected from hydrogen, halogen, C1-C6-alkyl, hydroxy-C1-C6-alkyl and C1-C6-alkyl-NH—C(O)—;
• or
• R1 and one occurrence of R2, taken together with the atoms to which they are attached, form a 3- to 14-membered heterocyclyl or a C3-C10-cycloalkyl, wherein said 3- to 14-membered heterocyclyl or C3-C10-cycloalkyl is optionally substituted with 1-2 substituents independently selected from halogen, cyano, hydroxy, amino, C1-C6-alkyl, C1-C6-alkoxy, halo-C1-C6-alkyl, halo-C1-C6-alkoxy and amino-C1-C6-alkyl-NH—;
• R3 is, at each occurrence, independently selected from hydrogen, halogen, C1-C6-alkoxy, cyano-C1-C6-alkoxy, halo-C1-C6-alkoxy, C2-C6-alkynyloxy, and (5- to 14-membered heteroaryl)oxy;
• R4 is selected from hydrogen and C1-C6-alkyl;
• R5 is selected from hydrogen and C1-C6-alkyl;
• or
• R6 is selected from C1-C6-alkyl, amino-C1-C6-alkyl, (3- to 14-membered heterocyclyl)-C(O)—NH—C1-C6-alkyl;
• wherein said 3- to 14-membered heterocyclyl is optionally substituted with 1-2 hydroxy substituents;
• R7, R8, and R9 are each independently selected from hydrogen, halogen, cyano, hydroxy, amino, C1-C6-alkyl, amino-C1-C6-alkyl, halo-C1-C6-alkyl, cyano-C1-C6-alkyl, hydroxy-C1-C6-alkyl, C1-C6-alkoxy, halo-C1-C6-alkoxy, C1-C6-alkyl-NH—C1-C6-alkyl, (C1-C6-alkyl)2N—C1-C6-alkyl, (C1-C6-alkyl)2N—C1-C6-alkyl-C(O)—, (C1-C6-alkyl)3N+—C1-C6-alkyl-C(O)—, (3- to 14-membered heterocyclyl)-C(O)—, amino-C1-C6-alkoxy-C1-C6-alkyl and oxo;
• wherein said 3- to 14-membered heterocyclyl is optionally substituted with 1-3 substituents selected from hydroxy, amino, halogen, cyano, C1-C6-alkyl, halo-C1-C6-alkyl, C1-C6-alkoxy, halo-C1-C6-alkoxy, and hydroxy-(3- to 14-membered heterocyclyl)-C(O)—;
• A is selected from 3- to 14-membered heterocyclyl, 5- to 14-membered heteroaryl, C6-C14-aryl, and C3-C10-cycloalkyl;
• L1 is a covalent bond or C1-C6-alkyl;
• m is an integer selected from 1, 2, 3 and 4;
• n is an integer selected from 1, 2, 3, 4 and 5;
• p is an integer selected from 0 and 1;
• q is an integer selected from 0 and 1;
• and
• r and s are both an integer selected from 1, 2, 3 and 4;
• provided that when X is carbonyl, R1 is not C1-C6-alkyl-NH— or (C1-C6-alkyl)2N—.