Substituted benzenecarboxamides as il-17a modulators

A compound represented by the structure of Formula IE:

• or a pharmaceutically acceptable salt thereof wherein:
• is selected from C3-6 carbocycle, 3- to 6-membered heterocycle, and 8- to 9-membered bicyclic heterocycle, any one of which is optionally substituted with one or more substituents independently selected from halogen, —OR11, —N(R11)2, —N(R11)S(O)2R11, —NO2, —CN, and C1-6 alkyl;
• is selected from cyclopentyl, cyclohexyl, and cycloheptyl each of which is optionally substituted with one or more substituents independently selected from halogen, —OR12, and optionally substituted C1-3 alkyl;
• R4 is
• wherein
• is selected from azetidine, piperidine, piperazine, morpholine, thiomorpholine, thiomorpholine 1,1-dioxide, and azaspiro[3.3]heptane any of which is optionally substituted with one or more substituents independently selected from halogen,
• —OR13, and optionally substituted C1-3 alkyl;
• RA is selected from hydrogen and fluorine;
• RB is selected from hydrogen, —OMe, —OEt, —CF3, —CHF2, —CH2F, methyl, ethyl, propyl, and isopropyl, wherein at least one of RA or RB is not hydrogen;
• R′ and R″ are each halogen;
• R1 is selected from —N(R21)C(O)R22, —N(R21)C(O)OR22, and —N(R21)C(O)N(R21)(R22);
• R21 is independently selected at each occurrence from hydrogen and C1-3 alkyl optionally substituted by one or more substituents independently selected from halogen, —OR17, —N(R17)2, and —CN;
• R22 is selected from (i), (ii), (iii), and (iv):
• (i) C1-6 alkyl optionally substituted by one or more substituents independently selected from halogen, —C(O)OR18, —OR18, and C3-6 cycloalkyl;
• (ii) C3-6 cycloalkyl optionally substituted by halogen, —OR18, C1-6 alkyl, and C1-6 haloalkyl;
• (iii) 3- to 6-membered monocyclic heterocycle optionally substituted with halogen, —OR18, C1-6 alkyl, C3-6 cycloalkyl, C3-6 cycloalkyl-C1-6 alkyl, C1-6 alkyl-(3- to 6-membered heterocycloalkyl);
• and
• (vi) 8- to 10-membered bicyclic heterocycle optionally substituted with halogen, —OR18, C1-6haloalkyl;
• and
• R11, R12, R13, R17, and R18 are independently selected at each occurrence from:
• hydrogen;
• C1-6 alkyl optionally substituted with one or more substituents independently selected from halogen, —OH, —O—C1-C6 alkyl, —O—C1-C6haloalkyl —NH2, —NO2, ═O, —CN, C3-10 carbocycle and 3- to 10-membered heterocycle;
• wherein the C3-10 carbocycle and 3- to 10-membered heterocycle are each optionally substituted with one or more substituents selected from:
• halogen, —OH, —O—C1-C6 alkyl, —O—C1-C6 haloalkyl —NH2, —NO2, ═O, and —CN;
• and
• C3-12 carbocycle and 3- to 12-membered heterocycle, each of which is optionally substituted with one or more substituents independently selected from:
• halogen, —OH, —O—C1-C6 alkyl, —O—C1-C6haloalkyl —NH2, —NO2, ═O, —CN;
• and
• C1-6 alkyl optionally substituted with one or more substituents independently selected from halogen, —OH, —O—C1-C6 alkyl, —O—C1-C6haloalkyl —NH2, —NO2, ═O, and —CN.