Evaporation strategy generated antibacterial enamel-like fluorapatite-polyacrylic acid sheet for functional dental restoration
AssigneeThe University of Hong Kong
InventorsHai Ming WONG, Quan Li LI, Le ZHANG
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Abstract
The subject invention pertains to an evaporation strategy combined with low-molecular-weight polyacrylic acid (LPAA) to generate an antibacterial dental enamel-like structure. Polystyrene (PS) plates can be used as a removable substrate for the continuous growth of fluorapatite (FAP). The FAP-LPAA composition can be used to kill microorganisms. The LPAA contained dental enamel-like FAP provides an alternative to prevent secondary caries if a carious cavity is filled with shaped dental enamel-like FAP-LPAA.
Claims16
A method of reducing bacteria in the mouth of a subject, the method comprising:
- contacting the mouth of the subject with an effective amount of a composition comprising low-molecular-weight polyacrylic acid (LPAA) and fluorapatite (FAP), according to the formulation Ca5(PO4)3F—(C3H4O2)n.
A method of replacement of decayed enamel tooth lesion sites or bone, the method comprising:
- contacting one or more teeth or bone of a subject with an effective amount of a composition comprising LPAA and FAP, according to the formulation Ca5(PO4)3F—(C3H4O2)n.
A method of synthesizing a FAP-LPAA sheet, according to the formulation Ca5(PO4)3F—(C3H4O2)n, said method comprising:
- i. providing a polymer plate;
- ii. immersing the polymer plate in a polydopamine solution;
- iii. optionally, fixing plastic foams on the polydopamine-activated polymer plate;
- iv. incubating the polymer plate in a calcification solution comprising LPAA and fluorine ion according to the formulation Ca5(PO4)3F;
- and
- v. dissolving the polymer plate with a solvent to obtain the FAP-LPAA sheet, according to the formulation (Ca5(PO4)3F—(C3H4O2)n).
A composition comprising LPAA and FAP, according to the formulation Ca5(PO4)3F—(C3H4O2)n.
Dependencies are inferred from the claim text.