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US 2023/0140994 A1Published application
Replication-deficient avian adenoviral vectors, their design and uses
AssigneeGreffex, Inc.
InventorUwe D. STAERZ
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AssigneeGreffex, Inc.
InventorUwe D. STAERZ
Estimating the term…
The embodiments disclosed herein relate to the design, engineering and production of replication-deficient gene delivery vectors that are based on aviadenoviruses. More particularly their use is described in the transfer of genes, genetic engineering of cells and animals, the expression of proteins the development of vaccines. In some embodiment, the designs and packaging of partially deleted aviadenovirus vectors are disclosed. In other embodiments, the designs and packaging of fully deleted aviadenovirus vectors, the propagation of replication-deficient aviadenovirus vectors, and the characteristic and engineering of host cells are disclosed. In other embodiments, the use of such vectors in veterinary medicine is described.
An aviadenoviral gene transfer vector comprising a deleted avidenoviral genome wherein the aviadenoviral vector is replication deficient and has a partial deletion of its genome.
An aviadenoviral complimentary genome construct, wherein the open reading frames 1, 15 and 2 of the CELO genome are expressed.
An aviadenoviral complimentary genome construct of claim 9, wherein the open reading frames 1, 15 and 2 are carried with a CELO genome fragment.
A packaging and host cell for aviadenoviral vectors comprising an avian cell.
A replication and encapsidation scheme for a replication-deficient aviadenoviral vector comprising:
An aviadenoviral packaging expression vector, comprising a CELO aviadenovirus derived genome deleted of the packaging signal Ψ.
A replication and encapsidation scheme for fully deleted “gutted” aviadenoviral vector comprising:
Dependencies are inferred from the claim text.