Back to results
US 2023/0137849 A1Published application
Use of a compound of the diuretics class for treating cancer
AssigneeAzelead
InventorsLaura FONTENILLE, Amel KISSA, Karima KISSA
Life of this patent
Estimating the term…
Abstract
Disclosed is a cancer treatment method utilizing a compound of the diuretics class. Also disclosed is a pharmaceutical composition used in such cancer treatment method, the compound being althiazide.
Claims21
-21. (canceled)
Method of treatment of cancer comprising administering to a subject a compound of formula (II)
- in which:
- a can represent:
- nothing,
- a single bond,
- a double bond;
- b represents:
- nothing if a represents nothing,
- a single bond if a is either a single bond or a double bond;
- the value of i being:
- zero if a represents nothing,
- equal to 1 if a is a single or a double bond;
- if a represents nothing, then b represents nothing and i is 0:
- R1 and R5 can represent independently of one another:
- H;
- a linear or branched alkyl or alkenyl chain of 1 to 20 carbon atoms, monocyclic, bicyclic or polycyclic of 3 to 20 carbon atoms;
- an aryl group of 1 to 20 carbons;
- R3 and R7 can represent independently of one another:
- H;
- a linear or branched alkyl or alkenyl chain of 1 to 20 carbon atoms, monocyclic, bicyclic or polycyclic of 3 to 20 carbon atoms;
- an aryl group of 1 to 20 carbonss;
- R4 can represent:
- H;
- a halogen atom
- a linear or branched alkyl or alkenyl chain of 1 to 20 carbon atoms, monocyclic, bicyclic or polycyclic of 3 to 20 carbon atoms;
- if a represents a single bond, then b represents a single bond and i is equal to 1:
- R1 can represent:
- H;
- a linear or branched alkyl or alkenyl chain of 1 to 20 carbon atoms, monocyclic, bicyclic or polycyclic of 3 to 20 carbon atoms;
- an aryl group of 1 to 20 carbonss;
- R2 can represent:
- H;
- a linear or branched alkyl or alkenyl chain of 1 to 20 carbon atoms, monocyclic, bicyclic or polycyclic of 3 to 20 carbon atoms;
- an aryl group of 1 to 20 carbons;
- R3 can represent:
- H;
- a linear or branched alkyl or alkenyl chain of 1 to 20 carbon atoms, monocyclic, bicyclic or polycyclic of 3 to 20 carbon atoms;
- an aryl group of 1 to 20 carbons;
- R5 and R7 represent nothing
- R6 represents H
- R4 is as defined above
- if a represents a double bond, then b represents a single bond and i is 1:
- R1, R5, R6 and R7 represent nothing;
- R2, R3 and R4 are as defined above.
40 more elements
Pharmaceutical composition containing a compound of formula (IA) or (IB), in combination with a pharmacologically acceptable carrier,
- said compound formula (IA) or (IB) being in pure form or with a chiral purity greater than 99%
Dependencies are inferred from the claim text.