Pharmaceutical compositions comprising amphiphilic peptides and methods of use thereof

A pharmaceutical composition comprising:

• (i) at least one amphiphilic peptide comprising alternating hydrophobic/hydrophilic amino acid residues, or a derivative or a salt thereof, wherein the peptide comprises 2-20 pairs of hydrophobic-hydrophilic alternating amino acid residues wherein the hydrophilic amino acid residue is selected from the group consisting of a negatively charged amino acid, a hydroxyl-containing amino acid, and a phosphorylated-hydroxyl-containing amino acid, and wherein said peptide has no more than 10% positively charged amino acid residues, and
• (ii) an antibiotic selected from the group consisting of a tetracycline, a penicillin, a cephalosporin, an aminoglycozide, a glycopeptide, chloramphenicol, a quinolone, a sulphonamide, 5-nitroimidazole, an ansamycin, a macrolide, and a mixture or combination thereof.