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US 2023/0128029 A1Published application
Neurokinin antagonists and uses thereof
AssigneeCalifornia Institute of Technology
InventorsDavid J. Anderson, Moriel Zelikowsky, Andrea Choe
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Abstract
In some embodiments, methods of inhibiting, ameliorating, reducing the severity of, treating, reducing the likelihood of, or preventing social isolation stress or symptoms thereof in a subject in need thereof are described. In some embodiments, methods of determining a risk of social isolation stress in a subject are described.
Claims19
A method of inhibiting, ameliorating, reducing the severity of, or treating one or more symptoms caused by social isolation stress, the method comprising:
- identifying a subject as suffering from social isolation stress and in need of inhibiting, ameliorating, reducing the severity of, or treating one or more symptoms caused by the social isolation stress;
- and
- administering an effective amount of a neurokinin receptor antagonist to the subject, wherein the neurokinin receptor antagonist is a NK3R antagonist, to thereby inhibit, ameliorate, reduce the severity of, or treat the one or more symptoms caused by the social isolation stress.
A method of determining a risk of social isolation stress in a subject, the method comprising:
- obtaining a sample from a peripheral tissue of the subject that is outside of the central nervous system;
- detecting a level of neurokinin in the sample;
- and
- determining the subject to be in need of the neurokinin receptor antagonist if the level of neurokinin in the sample is greater than a control level of neurokinin.
1 more element
Dependencies are inferred from the claim text.