Growth factor formulation for condition associated with otic event

A method of treating an otic disease or condition associated with a synapses-affecting event in a subject in need thereof, the method comprising administering an otic formulation comprising a therapeutically effective amount of a growth factor and an auris-acceptable vehicle within 14 days after onset of the synapses-damaging event, wherein the otic formulation is formulated to provide sustained release of the growth factor into the inner ear to promote formation of synapses or repaire damaged synapses.