A method for treating psoriasis or a tumor in a biological subject, comprising administrating to the biological subject a high penetration compound of Structure 1, or a stereoisomer or a pharmaceutically acceptable salt thereof, wherein Structure 1 is selected from Structure 1a, Structure 1b, Structure 1c, Structure 1d, Structure 1e, Structure 1g, and Structure 1m, having the following chemical structures:
- wherein, in any of Structure 1a, Structure 1b, Structure 1c, Structure 1d,
- Structure 1 e, Structure 1g, and Structure 1m, is selected from Structure Y-a, Structure Y-b, and Structure Y-c:
- is selected from substituted and unsubstituted aryl, Structure Ar-a, Structure Ar-b, Structure Ar-c, Structure Ar-d, Structure Ar-e, Structure Ar-f, Structure Ar-g, Structure Ar-h and Structure Ar-i:
- R4 is selected from unsubstituted alkyl, substituted and unsubstituted alkoxyl, substituted and unsubstituted perfluoroalkyl, substituted and unsubstituted alkyl halide, substituted and unsubstituted aryl, and substituted and unsubstituted heteroaryl groups;
- X3-X4 are independently selected from NHCOR5, OR5, SRS, NHR5, OCOR5, R5, substituted and unsubstituted alkoxyl, substituted and unsubstituted alkylthio, substituted and unsubstituted alkylamino, substituted and unsubstituted alkyl halide, H, F, Cl, Br, I, NO2, CN, CF3, NHCOCH3, OCH3, SCH3, NH2, NHCH3, OCOCH3, OCOC2H5, OC2H5, OC3H7, CH3, C2H5, and C3H7;
- X5-X7 are independently selected from NHCOR4, OR4, SR4, NHR4, OCOR4, R4, substituted and unsubstituted alkoxyl, substituted and unsubstituted alkylthio, substituted and unsubstituted alkylamino, substituted and unsubstituted alkyl halide, H, F, Cl, Br, I, NO2, CN, CF3, NHCOCH3, OCH3, SCH3, NH2, NHCH3, OCOCH3, OCOC2H5, OC2H5, OC3H7, CH3, C2H5, and C3H7;
- z is an integer;
- Y1 is selected from CH2, O, S, and NH;
- Y2 and Y3 are the same or different and each is NHCOR4, H, OH, NHCOCH3, NHCOC2H5, Cl, F, Br, or I, or taken together is ═O;
- Y4 is selected from R4, CH2, —(CH2)n—, O, S, and NH;
- A is selected from amino acids, α-amino acids and β-amino acids residues;
- any CH2 groups may be replaced with O, S, or NH;
- and
- when a bond is not linked with any atom of an aryl or heteroaryl ring, the bond can be put into any position of the ring;
- R is independently selected from substituted and unsubstituted 0-20 carbon atoms alkylene, substituted and unsubstituted 1-20 carbon atoms perfluoroalkylene, substituted and unsubstituted 2-20 carbon atoms alkenylene, substituted and unsubstituted 2-20 carbon atoms alkynylene, substituted and unsubstituted 6-20 carbon atoms arylene, and substituted and unsubstituted 2-20 carbon atoms heteroarylene;
- R1 and R2 in Structure 1a are same or different and each independently selected from H, substituted and unsubstituted alkyl, substituted and unsubstituted cycloalkyl, substituted and unsubstituted heterocycloalkyl, substituted and unsubstituted aryl, substituted and unsubstituted heteroaryl;
- R11, and R12 in Structure 1b and Structure 1c are each independently substituted or unsubstituted alkylene;
- R13 in Structure 1b are each independently substituted or unsubstituted alkylene;
- R5 in Structure 1c, Structure 1e, Structure 1g, and Structure 1m is selected from H, substituted and unsubstituted alkyl, substituted and unsubstituted cycloalkyl, substituted and unsubstituted heterocycloalkyl, substituted and unsubstituted aryl, substituted and unsubstituted heteroaryl;
- R11 and R13 in Structure 1g and Structure 1m are each independently substituted or unsubstituted methine, and R12 is substituted or unsubstituted alkylene;
- X is selected from O, S, NRS, and NH;
- X1 and X2 are independently selected from Cl, Br, F, and OSO2R5;
- and
- HA is selected from nothing, hydrochloride, hydrobromide, hydroiodide, nitric acid, sulfic acid, bisulfic acid, phosphoric acid, phosphorous acid, phosphonic acid, isonicotinic acid, acetic acid, lactic acid, salicylic acid, citric acid, tartaric acid, pantothenic acid, bitartaric acid, ascorbic acid, succinic acid, maleic acid, gentisinic acid, fumaric acid, gluconic acid, glucaronic acid, saccharic acid, formic acid, benzoic acid, glutamic acid, methanesulfonic acid, ethanesulfonic acid, benzensulfonic acid, p-toluenesulfonic acid and pamoic acid.