Back to results
US 2023/0089353 A1Published application
Method for the preparation of n-monofluoroalkyl tropanes and their use
AssigneeRotop Radiopharmacy GmbH
InventorsKritee PANT, Felix ROSCHKE
Life of this patent
Estimating the term…
Abstract
The present invention relates to a method for the preparation of an N-monofluoroalkyl tropane, a method for the preparation of a trialkyltin tropane, a method for the preparation of an iodinated and/or radioiodinated tropane and the use of the N-monofluoroalkyl tropane as a precursor in the method for the preparation of the trialkyltin tropane and/or the iodinated and/or radioiodinated tropane.
Claims20
A method for the preparation of an N-monofluoroalkyl tropane of formula (VI)
- wherein n is 2, 3 or 4,
- comprising the steps:
- a) provision of a compound of formula (I)
- b) reduction of the carbonyl group to a hydroxyl group to give the compound of formula (II)
- c) dehydration reaction to give the compound of formula (III)
- d) addition of a 4-bromophenyl moiety to give the compound of formula (IV)
- e)N-demethylation to give the compound of formula (V)
- f) alkylation with an alkylation agent of formula F—(CH2)n—Br in the presence of a base
- to give the N-monofluoroalkyl tropane of formula (VI),
- wherein n is 2, 3 or 4.
7 more elements
Dependencies are inferred from the claim text.