Methods and compositions for modulating splicing

A compound of Formula (III), or a pharmaceutically acceptable salt or pharmaceutically acceptable solvate thereof:

• wherein,
• A is —O—, —S—, or —N(RN)—;
• E is —NR—, —O—, —S—, —S(═O)—, —S(═O)2—, or —S(═O)(═NRE)—;
• RE is hydrogen, substituted or unsubstituted C1-C3 alkyl, substituted or unsubstituted C3-C6 cycloalkyl, substituted or unsubstituted C2-C5 heterocycloalkyl, substituted or unsubstituted C2-C3 alkenyl, or substituted or unsubstituted C2-C3 alkynyl;
• RN is hydrogen, substituted or unsubstituted C1-C3 alkyl, substituted or unsubstituted C3-C6 cycloalkyl, substituted or unsubstituted C2-C5 heterocycloalkyl, substituted or unsubstituted C2-C3 alkenyl, or substituted or unsubstituted C2-C3 alkynyl;
• ring Q is substituted or unsubstituted aryl or substituted or unsubstituted heteroaryl;
• is a single bond or a double bond;
• X is
• and Z is C;
• or
• X is —O—, —S—, —NR3—,
• and Z is CR2;
• W is substituted or unsubstituted C1-C3 alkylene, substituted or unsubstituted C2-C3 alkenylene, substituted or unsubstituted C1-C2 heteroalkylene, substituted or unsubstituted C3-C8 cycloalkylene, or substituted or unsubstituted C2-C7 heterocycloalkylene;
• R is hydrogen, substituted or unsubstituted C1-C4 alkyl, substituted or unsubstituted C1-C4 fluoroalkyl, substituted or unsubstituted C1-C4 heteroalkyl, substituted or unsubstituted C3-C6 cycloalkyl, or substituted or unsubstituted C2-C5 heterocycloalkyl;
• each R1 is independently hydrogen, deuterium, substituted or unsubstituted C1-C4 alkyl, —CD3, substituted or unsubstituted C1-C4 haloalkyl, substituted or unsubstituted C1-C4 heteroalkyl, substituted or unsubstituted C3-C6 cycloalkyl, substituted or unsubstituted C2-C5 heterocycloalkyl, substituted or unsubstituted aryl, or substituted or unsubstituted heteroaryl;
• R2 is hydrogen, deuterium, substituted or unsubstituted C1-C4 alkyl, —CD3, or substituted or unsubstituted C1-C4 haloalkyl;
• R3 is hydrogen, —CN, substituted or unsubstituted C1-C4 alkyl, —CD3, substituted or unsubstituted C1-C4 haloalkyl, substituted or unsubstituted C1-C4 heteroalkyl, —C1-C4 alkylene-OR1, substituted or unsubstituted C3-C4 cycloalkyl, or substituted or unsubstituted C2-C3 heterocycloalkyl;
• each R4 is independently hydrogen, deuterium, substituted or unsubstituted C1-C4 alkyl, —CD3, substituted or unsubstituted C1-C4 haloalkyl, or substituted or unsubstituted C1-C4 heteroalkyl;
• each R11, R12, R13, R14, R16, and R17 is independently selected from the group consisting of hydrogen, deuterium, F, —OR1, substituted or unsubstituted C1-C4 alkyl, a substituted or unsubstituted C1-C4 fluoroalkyl, and substituted or unsubstituted C1-C4 heteroalkyl;
• R15 and R18 are independently selected from the group consisting of hydrogen, deuterium, F, —OR1, substituted or unsubstituted C1-C4 alkyl, a substituted or unsubstituted C1-C4 fluoroalkyl, and substituted or unsubstituted C1-C4 heteroalkyl;
• a is 0, b is 0, c is 1, and d is 1;
• or
• a is 1, b is 0, c is 1, and d is 0.