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US 2023/0069723 A1Published application
Methods of Hydromethylation of Alkenes and Ketones
AssigneeThe Florida State University Research Foundation, Inc.
InventorsJames H. Frederich, James A. Law
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Abstract
Methods of hydromethylation of alkenes and ketones, including methods that use Tebbe's reagent. The methods may include contacting Cp2Ti(μ-Cl)(μ-CH2)AlMe2 and an alkene or a ketone to produce an intermediate product that may include a titanacyclobutane. The intermediate product may be contacted with an acid to produce a methylated product.
Claims20
A method of hydromethylation, the method comprising:
- contacting (i) an alkene or a ketone, and (ii) Cp2Ti(μ-Cl)(μ-CH2)AlMe2 to produce an intermediate product;
- contacting the intermediate product with an acid to produce a methylated product.
A method of hydromethylation, the method comprising:
- contacting (i) an alkene or a ketone, and (ii) Cp2Ti(μ-Cl)(μ-CH2)AlMe2 at a temperature less than 30° C. in the presence of a Lewis base to produce an intermediate product comprising a titanacyclobutane moiety;
- contacting the intermediate product with an acid to produce a methylated product.
Dependencies are inferred from the claim text.