Bioreactor

A cell culture bioreactor device, comprising:

• a culture chamber for biological cell growth, an external culture medium reservoir operationally connected to said culture chamber, a culture growing structure having a top end and at least one lower end mounted within said culture chamber, manifold mechanism in fluid communication with said culture medium reservoir for receiving and distributing culture medium, and supported directly above the top end of the culture growing structure, fluid circulation mechanism for moving culture medium from the reservoir through said culture growing structure, and aerating mechanism for introducing air into and removing air from said culture chamber, where the culture growing structure is at least one of 1) a support matrix using wicking and 2) a lattice structure, that is coated with a thermal responsive polymer, where a material of interest growing on the culture growing structure is removed by changing a temperature that the thermal responsive polymer on the surface of the culture growing structure is exposed to and release the thermal responsive polymer along with the material of interest from the remainder of the culture growing structure.