Use of rhodococcus ruber cell wall skeleton in regenerative medicine
AssigneeLiaoning Greatest Bio-Pharmaceutical Co., Ltd.
InventorsBo Gai, Chunyan Dou, Peisheng Jin, Yi Zhang, Guoying Zhang
Life of this patent
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Abstract
Provided is a use of Rhodococcus ruber cell wall skeleton in promoting the proliferation of stem cells, promoting the growth of stem cells, promoting the differentiation of stem cells, promoting the migration of stem cells, and improving the survival rate of stem cells; the stem cells are selected from: adult stem cells, iPSCs, and mesenchymal stem cells.
Claims21
1-13. (canceled)
A method of regulating stem cells comprising exposing the stem cells to a product derived from Rhodococcus ruber cell wall;
- wherein the ratio of the number of stem cells to the product derived from Rhodococcus ruber cell wall is 1 to 100 stem cells per 1 ng of the product derived from Rhodococcus ruber cell wall.
A cell culture medium comprising a product derived from Rhodococcus ruber cell wall, wherein the product derived from Rhodococcus ruber cell wall is Rhodococcus ruber cell wall or a component thereof.
A method for promoting wound healing, comprising exposing a subject having a wound to a therapeutically effective amount of stem cells and a product derived from Rhodococcus ruber cell wall, wherein the stem cells are selected from the group consisting of adult stem cells, mesenchymal stem cells and iPSCs and the ratio of the number of stem cells to the product derived from Rhodococcus ruber cell wall is 1 to 100 stem cells per 1 ng of the product derived from Rhodococcus ruber cell wall.
A pharmaceutical composition comprising:
- (i) stem cells, and
- (ii) a product derived from Rhodococcus ruber cell wall, wherein the stem cells are selected from the group consisting of adult stem cells, mesenchymal stem cells, iPSCs, or a combination thereof;
- and the ratio of the number of stem cells to the product derived from Rhodococcus ruber cell wall is:
- 1 to 100 stem cells to 1 ng of the product derived from Rhodococcus ruber cell wall.
Dependencies are inferred from the claim text.