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AssigneeProlacta Bioscience, Inc.
InventorsDavid N. COOK, Gregory MCKENZIE, Julie E. BUTTON
Estimating the term…
Provided herein are compositions, methods, strategies, kits, and articles of manufacture that are useful, inter alia, in the treatment or prevention of diseases or conditions such as those which may be associated with inflammation, infection, allergy, immune dysfunction, or dysbiosis of the intestinal microbiome. In some aspects, the invention provides a synergistic combination of a prebiotics, e.g., a mixture of human milk oligosaccharides, and a probiotic strain, such as a strain capable of internalizing and consuming the rebiotics, e.g., B. longum subsp. infantis.
A method for treating or preventing a disease, disorder, or condition associated with one or more of dysbiosis of the intestinal microbiome, inflammation, infection, allergy, or immune dysfunction in a subject in need thereof, the method comprising administering to the subject (i) a prebiotic mixture comprising one or more human milk oligosaccharides and (ii) at least one probiotic strain of bacterium comprising B. longum subsp. infantis, B. longum subsp. longum, B. breve, or B. bifidum.
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A method of reducing ammonia in a subject in need thereof, comprising administering to a subject (i) a prebiotic mixture of oligosaccharides, wherein all or essentially all of the oligosaccharides of the prebiotic mixture are human milk oligosaccharides (HMOs) that do not incorporate an N-acetyl glucosamine residue, and (ii) a probiotic strain of bacterium, wherein the probiotic strain of bacterium comprises B. longum subsp. infantis.
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Dependencies are inferred from the claim text.