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US 2023/0068879 A1Published application
Anti-dinitrophenol chimeric antigen receptors
AssigneeSeattle Children's Hospital (dba Seattle Children's Research Institute)
InventorsMichael C. Jensen, James F. Matthaei, Joseph K. Cheng
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Abstract
Embodiments provided herein include methods and compositions comprising anti-dinitrophenol chimeric antigen receptors (CARs). Some embodiments include nucleic acids encoding such CARs, polypeptides encoded by such nucleic acids, cells comprising such nucleic acids or polypeptides, and methods utilizing such cells. Some embodiments also include the use of dinitrophenol (DNP) and derivatives thereof.
Claims21
-64. (canceled)
A nucleic acid encoding a chimeric antigen receptor (CAR), wherein the CAR comprises:
- a ligand binding domain which specifically binds to a dinitrophenol (DNP) moiety, wherein the ligand binding domain comprises an amino acid sequence having at least 90% sequence identity to the amino acid sequence set forth in any one of SEQ ID NOs:01-12;
- a spacer;
- a transmembrane domain;
- and
- an intracellular signaling domain.
2 more elements
Dependencies are inferred from the claim text.