Mediation of in vivo analyte signal degradation

A method of fabricating a sensor for measurement of an analyte in a medium within a living animal, the method comprising:

• applying an analyte indicator to a sensor housing of the sensor such that the applied analyte indicator covers at least a portion of the sensor housing, wherein the analyte indicator comprises one or more compounds containing boronate or boronic acid moieties that reduce degradation of the analyte indicator, wherein the one or more compounds containing boronic acid containing moieties are a compound of Formula I:
• wherein R=methylene or an alkyl group, an aryl group, a heteroaryl group, a cyclic group, a multicyclic group, a polyalkylene glycol group, a polyethylene glycol (PEG) group, a linear or substituted polyalkylene glycol or PEG group, or a combination thereof, or a compound of Formula I wherein the boronic acid is substituted with a boronate group of Formula II:
• wherein X and Y=alkyl.