Microbiota-Derived Proteins Inducing Il-10 Release From Human Cells And Uses Thereof
AssigneeEnterome S.A.
InventorsAntoinetta CULTRONE, Laurent CHENE, Francesco STROZZI, Christophe BONNY
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Abstract
The present invention relates to microbiota-derived proteins, which are capable of inducing and/or enhancing secretion of IL-10 from human cells. Accordingly, the present invention provides microbial proteins, and fragments and sequence variants thereof, which stimulate IL-10 release from human immune cells. The present invention also relates to nucleic acids encoding such proteins, cells expressing such proteins, respective pharmaceutical compositions and uses thereof.
Claims43
An isolated protein of non-pathogenic microbiota, or a fragment or sequence variant thereof, which is capable of inducing and/or enhancing IL-10 secretion from human cells.
A protein comprising or consisting of an amino acid sequence sharing at least 80% sequence identity with any one of SEQ ID NOs 1 to 10.
Dependencies are inferred from the claim text.