Stabilization of selenite in a nutritional solution by dissolved oxygen
AssigneesBaxter International Inc., Baxter Healthcare S.A.
InventorsCaroline DUPONT, Zouaoui BOUREZG
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Abstract
The invention relates to a medical product for preventing or correcting selenium deficiency in a patient comprising a solution provided in a flexible container comprising at least one selenium compound in the form of Se (IV), which is preferably selected from the group consisting of sodium selenite, selenous acid and selenium dioxide, characterized in that the solution comprises dissolved oxygen (DO), preferably 0.5 ppm to 8 ppm DO.
Claims21
A medical product for preventing or correcting selenium deficiency in a patient comprising a solution provided in a flexible container comprising at least one selenium compound in the form of Se(IV), which is preferably selected from the group consisting of sodium selenite, selenous acid and selenium dioxide, characterized in that the solution comprises from 0.5 ppm to 8 ppm dissolved oxygen (DO).
A method of preparing a medical product for preventing or correcting selenium deficiency in a patient according to any one of the preceding claims, wherein the solution is prepared by the steps comprising
- a. dissolving at least one selenium compound in the form of Se(IV), which is preferably selected from sodium selenite, selenous acid and/or selenium dioxide, in a liquid medium, preferably water for injection, to produce a solution, with a concentration of selenium between 0.28 and 28 mg/L,
- b. optionally further dissolving, alone or together with the selenium compound in the form of Se(IV), an acid, preferably an organic acid selected from the group comprising malic acid, tartaric acid, citric acid, maleic acid and fumaric acid, and/or at least one additional trace element selected from the group comprising zinc, iron, copper, manganese, chromium, iodine, fluoride and molybdenum,
- c. adjusting the solution to a concentration of dissolved oxygen of from 0.5 ppm to 8 ppm,
- d. sterilizing the solution, preferably by heat sterilization.
A sterilized solution for parenteral administration comprising at least one selenium compound in the form of Se(IV), which is preferably selected from the group comprising sodium selenite, selenous acid and selenium dioxide, for use in preventing or correcting selenium deficiency in a patient, characterized in that the solution comprises dissolved oxygen (DO).
Dependencies are inferred from the claim text.