Macrolide compound and its use of treatment chronic respiratory disease

A compound of formula I, or a pharmaceutically acceptable salt, a stereoisomer thereof;

• Wherein,
• Rn1 is selected from the group consisting of H, C1-6 alkyl (preferably methyl);
• Rn2 is a substituted or unsubstituted group selected from the group consisting of H, C1-10 alkyl, —C1-4 alkylene-C6-10 aryl, —C1-4 alkylene- (5- to 10-membered heteroaryl), C1-6 alkanoyl (C1-6 alkyl-C(O)—), —C1-6 alkanoyl-C6-10 aryl, —C1-6alkanoyl- (5- to 10-membered heteroaryl) C1-6 alkoxycarbonyl (C1-6 alkyl-OC (O)—), —C1-6 alkoxycarbonyl-C6-10 aryl, —C1-6alkoxycarbonyl- (5- to 10-membered heteroaryl), C2-10 alkenyl, and C2-10 alkynyl;
• R12 and R13 are independently selected from the group consisting of H, substituted or unsubstituted C1-6 alkyl, substituted or unsubstituted C3-6 cycloalkyl, R5—C(O)—, and R5—OC(O)—;
• R21, R22, R23, R24, R25 and R26 are independently selected from the group consisting of H, and Substituted or unsubstituted C1-6 alkyl (preferably methyl);
• R4 is selected from the group consisting of:
• H, substituted or unsubstituted C1-6 alkyl, substituted or unsubstituted C3-6 cycloalkyl, R5—C(O)—, R5—OC(O)—, and
• wherein,
• R41 and R42 are independently selected from the group consisting of:
• H, substituted or unsubstituted C1-6 alkyl;
• R43 is selected from the group consisting of:
• H, substituted or unsubstituted C1-6 alkyl, Substituted or unsubstituted C1-6 alkanoyl;
• R44 is selected from the group consisting of:
• H, substituted or unsubstituted C1-6 alkyl, Substituted or unsubstituted C1-6 alkanoyl;
• is a double bond or single bond;
• R11 is selected from the group consisting of H, substituted or unsubstituted C1-6 alkyl, substituted or unsubstituted C3-6 cycloalkyl, R5—C(O)—, and R5—OC(O)—;
• or R11 is null, and when R11 is null, a single bond is formed between O to which R11 attached and A;
• A is selected from the group consisting of —C(O)—, —N(R6)—(C(R′)2)—, —CR′(R7)—, —C(═N(ORs))—,
• —CR′═, —CR′—;
• R6 is selected from the group consisting of H, Substituted or unsubstituted C1-6 alkyl;
• R7 is selected from the group consisting of:
• H, —OH, Substituted or unsubstituted C1-6 alkyl, Substituted or unsubstituted C1-6 alkoxy, Substituted or unsubstituted C1-6 alkyl-C(O)O—, Substituted or unsubstituted —N (R′)2;
• R8 is selected from the group consisting of H, —C1-6 alkyl, —C1-4 alkylene-C2-C6alkenyl, —C1-4 alkylene-C2-C6 alkynyl, —C1-4 alkylene-O—C1-6 alkyl, —C1-4 alkylene-S—C1-6 alkyl, —C1-4 alkylene-O—C1-4 alkylene-O—C1-6 alkyl;
• wherein R8 can further be optionally substituted with a substituent selected from the group consisting of —OH, —CN, substituted or unsubstituted C1-6 alkyl, substituted or unsubstituted C6-10 aryl, substituted or unsubstituted 5- to 10-membered heteroaryl, substituted or unsubstituted —N(R′)2, substituted or unsubstituted C5-7 heterocycloalkyl, substituted or unsubstituted C3-8 cycloalkyl;
• R5 is selected from the group consisting of:
• H, substituted or unsubstituted C1-6 alkyl, substituted or unsubstituted —C1-6 alkylene-C6-10 aryl, substituted or unsubstituted 5- to 10-membered heteroaryl;
• R′ is selected from the group consisting of:
• H, substituted or unsubstituted C1-6 alkyl;
• unless otherwise specified, the term “substituted” refers to one or more (preferably 1, 2, 3, 4 or 5) hydrogen in the group is substituted with a substituent selected from the group consisting of D, halogen, —OH, C1-6 alkyl, C1-6 haloalkyl.