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AssigneesUniversity of Massachusetts, The Johns Hopkins University, Kennedy Krieger Institute, Inc.
InventorsMiguel Sena Esteves, Sourav Roy Choudhury, Kathryn Rae Wagner, Jennifer Gifford Green, Ana Rita Batista
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The disclosure relates, in some aspects, to adeno-associated virus capsid proteins isolated from an in vivo library and recombinant adeno-associated viruses (rAAVs) comprising the same. In some aspects, the disclosure relates to isolated nucleic acids encoding AAV capsid proteins isolated from an in vivo library. In some embodiments, rAAVs and compositions described by the disclosure are useful for delivery of one or more transgenes to the muscle-tissue of a subject.
An isolated nucleic acid comprising the sequence set forth in SEQ ID NOs:
An isolated AAV capsid protein comprising the amino acid sequence set forth in SEQ ID NOs:
3-6. (canceled)
8-15. (canceled)
29-31. (canceled)
A kit for producing an rAAV, the kit comprising:
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45-47. (canceled)
Dependencies are inferred from the claim text.