Iron oxide nanoparticle for targeted chemo-immunotherapy
AssigneeUniversity of Washington
InventorsMiqin Zhang, Qingxin Mu, Guanyou Lin
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Abstract
Multifunctional nanoparticle for targeted therapeutic drug delivery, comprising (a) an iron oxide core having silica-polyethylene glycol coupled thereto to provide an iron oxide coated core, (b) a cytotoxic agent reversibly associated with the coated core; (c) an immunomodulating agent reversibly associate with the coated core; and (d) a tumor targeting agent associated with the coated core. Methods for using the nanoparticle to treat cancers and methods for making the nanoparticle.
Claims20
A nanoparticle for targeted therapeutic drug delivery, comprising:
- (a) an iron oxide core having silica-polyethylene glycol coupled thereto to provide an iron oxide coated core;
- (b) a cytotoxic agent reversibly associated with the coated core;
- (c) an immunomodulating agent reversibly associated with the coated core;
- and
- (d) a tumor targeting agent associated with the coated core.
A method for making a multifunctional nanoparticle, comprising:
- (a) forming a layer of silica-polyethylene glycol surrounding an iron oxide core to provide a coated iron oxide core;
- (b) associating a tumor targeting agent to the coated core;
- (c) forming a first layer of a cytotoxic agent surrounding the coated core;
- and
- (d) forming a second layer of an immunomodulating agent surrounding the first layer to provide a nanoparticle comprising a tumor targeting agent, a cytotoxic agent, and an immunomodulating agent.
Dependencies are inferred from the claim text.