Novel pyrazole derivative

A compound represented by Chemical formula I below, a solvate, a stereoisomer or a pharmaceutically acceptable salt.

• In the formula,
• X, Y are CR1R2 or NR3;
• and
• R1, R2 or R3 is same or different each other, and is each independently selected from Ra-L-, Ra-L-CO—, Ra-L-NHCO—, Ra-L-OCO—, Ra-L-SO2—;
• and
• the Ra is selected from hydrogen, heavy hydrogen, cyan, halogen, nitro, haloalkyl, substituted or non-substituted C1-C10 linear or branched alkyl, substituted or non-substituted C3-C8 cycloalkyl, substituted or non-substituted C5-C20 aryl, or substituted or non-substituted C5-C20 heteroaryl, and the heteroaryl comprises 1, 2 or 3 heteroatoms among O, N and S;
• and
• the L is selected from direct boding, C1-C5 alkylene and substituted or non-substituted C5-C10 arylene;
• and
• the R4 is selected from hydrogen or substituted or non-substituted C1-C10 alkyl;
• and
• A is CR5 or N, B, and CR6 or N, D is CR7 or N, and E is CR8 or N, and G is CR9 or N;
• and
• the R5 to R9 are same or different, and are each independently selected from hydrogen, heavy hydrogen, cyan, halogen, haloalkyl, carbonyl, nitro, carboxyl, C1-C5 alkoxy, substituted or non-substituted C1-C10 linear or branched alkyl, substituted or non-substituted C3-C8 cycloalkyl, substituted or non-substituted amine, substituted or non-substituted C5-C20 aryl, or substituted or non-substituted C5-C20 heteroaryl, and two or more groups adjacent to each other may combine with each other to form a substituted or non-substituted aromatic hydrocarbon ring, wherein the aromatic hydrocarbon ring may form a C5-C10 heteroaryl ring or aryl ring comprising 0, 1, 2 or 3 heteroatoms selected from N, O and S;
• and
• the substituted C1-C10 linear or branched alkyl may be optionally partially unsaturated, and may be independently substituted to one or more substituents selected from heavy hydrogen, halogen, cyan, nitro, carboxyl, substituted or non-substituted amine, substituted or non-substituted C5-C20 aryl or C5-C20 heteroaryl, substituted or non-substituted C3-C8 cycloalkyl;
• and
• the substituted C3-C8 cycloalkyl may be substituted independently as one or more substituents selected from heavy hydrogen, halogen, cyan, nitro, carboxyl, substituted or non-substituted amine, substituted or non-substituted C5-C20 aryl or C5-C20 heteroaryl, C1-C5 alkoxy and C1-C5 haloalkyl or same or different 2 or more substituents are linked;
• and
• the substituted C5-C20 aryl or substituted C5-C20 heteroaryl may be substituted independently as one or more substituents selected from heavy hydrogen, halogen, cyan, nitro, carboxyl, substituted or non-substituted amine, C1-C5 alkoxy, C1-C5 haloalkyl, C1-C10 alkyl C3-C8 cycloalkyl, C1-C10 alkyl, C5-C20 aryl C1-C10 alkyl or same or different 2 or more substituents are linked;
• the substituted amine may be substituted to one or two of C1-C5 alkyl groups;
• and
• the substituted C5-C10 arylene may be substituted to one or more substituents selected from C1-C3 alkyl, halogen, cyan, amine, nitro and heavy chain or same or different 2 or more substituents are linked.