Cancer gene therapy drug
AssigneeNational University Corporation Kobe University
InventorsToshiro SHIRAKAWA, Naoto KUNIMURA, Koichi KITAGAWA
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Abstract
Provided is a novel cancer gene therapeutic means. More specifically, provided is a nucleic acid having a structure in which (A) a nucleic acid encoding a protein having a CD44 extracellular function, (B) a nucleic acid encoding a protein having a Notch core region function, and (C) a nucleic acid encoding a protein having an HIF-3α4 function are linked in the order of (A)-(B)-(C).
Claims12
A nucleic acid having a structure in which (A) a nucleic acid encoding a protein having a CD44 extracellular function, (B) a nucleic acid encoding a protein having a Notch core region function, and (C) a nucleic acid encoding a protein having an HIF-3α4 function are linked in an order of (A)-(B)-(C).
A nucleic acid having a structure in which nucleic acid (A), nucleic acid (B), and nucleic acid (C) are linked in an order of (A)-(B)-(C);
- nucleic acid (A) being:
- (a-1):
- a nucleic acid consisting of a base sequence of SEQ ID NO:
- 1, or
- (a-2):
- a nucleic acid consisting of a base sequence having deletion, substitution, or addition of one or more bases in the base sequence of (a-1), and encoding a protein that can bind to hyaluronic acid;
- nucleic acid (B) being:
- (b-1):
- a nucleic acid consisting of a base sequence of SEQ ID NO:
- 2, or
- (b-2):
- a nucleic acid consisting of a base sequence having deletion, substitution, or addition of one or more bases in the base sequence of (b-1), and encoding a protein that can be cleaved by a protease;
- and
- nucleic acid (C) being:
- (c-1):
- a nucleic acid consisting of a base sequence of SEQ ID NO:
- 3, or
- (c-2):
- a nucleic acid consisting of a base sequence having deletion, substitution, or addition of one or more bases in the base sequence of (c-1), and encoding a protein that can bind to HIF-1α.
A nucleic acid that is:
- (d-1) a nucleic acid consisting of a base sequence of SEQ ID NO:
- 4;
- (d-2) a nucleic acid consisting of a base sequence having deletion, substitution, or addition of one or more bases in the base sequence of SEQ ID NO:
- 4, and having a structure in which a portion encoding a protein that can bind to hyaluronic acid, a portion encoding a protein that can be cleaved by a protease, and a portion encoding a protein that can bind to HIF-1α are linked in this order;
- or
- (d-3) a nucleic acid consisting of a base sequence having deletion, substitution, or addition of one or more bases in the base sequence of SEQ ID NO:
- 4, and encoding a protein having anti-cancer activity.
Dependencies are inferred from the claim text.