Methods for treating inflammatory conditions of the lungs
AssigneeDefensin Therapeutics ApS
InventorsPeter Nordkild, Søren Kjærulff
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Abstract
The present invention relates to methods for treatment or prevention of asthma, mild intermittent asthma, mild persistent asthma, moderate persistent asthma, severe persistent asthma, eosinophilic asthma, neutrophilic asthma, steroid refractory asthma, status asthmaticus, pneumonia, bronchiectasis, COPD, sarcoidosis, and lung cancer based on reducing airway hyper responsiveness, increasing pulmonary compliance, reducing lung inflammation, reducing inflammatory cell count in bronchoalveolar fluid and reducing cytokine production by administration of a mammalian α- and/or β-defensin.
Claims20
1-28. (canceled)
A method of treatment of asthma, bronchiectasis, chronic obstructive pulmonary disorder (COPD) or emphysema, the method comprising oral or intrapulmonary administration of at least one defensin selected from the group consisting of HD5, HD6, hBD1, hBD2, hBD3, hBD4, and hBD2 N-terminally truncated by 1-4 amino acids to a subject in need thereof.
A method of treatment of steroid refractory asthma, the method comprising oral administration of hBD2 to a subject in need thereof.
A method of treatment of COPD, the method comprising oral administration of hBD2 to a subject in need thereof.
Dependencies are inferred from the claim text.