Peptides useful in preservation and/or restoration of functional pancreatic islets and in treating diabetes
AssigneesThe National Institute for Biotechnology In the Negev Ltd., B. G. Negev Technologies and Applications Ltd., At Ben-Gurion University
InventorVarda SHOSHAN-BARMATZ
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Abstract
The present invention relates the field of preservation of functional pancreatic islet and treatment of diabetes, particularly to the use of peptides comprising analogues, particularly retro-analogues of VDAC1-derived peptides, for treating diabetes.
Claims21
1-42. (canceled)
A method for treating diabetes and/or preventing the progress of diabetes, comprising administering to a subject affected with prediabetes or with diabetes a therapeutically effective amount of a pharmaceutical composition comprising at least one synthetic peptide comprising a retro modified and partially or completely inverso modified analogue of a VDAC1-derived peptide, wherein the VDAC1-derived peptide comprises an amino acid sequence selected from the group consisting of SEQ ID NO:1 and SEQ ID NO:2.
Dependencies are inferred from the claim text.