Substituted nucleoside analogs as prmt5 inhibitors

A compound of general formula (I), its stereoisomer, or its pharmaceutically acceptable salt,

• wherein,
• L1 is selected from —CRaRb—, —NRa—, S, and O;
• Ra and Rb are independently selected at each occurrence from hydrogen, substituted or unsubstituted alkyl, and substituted or unsubstituted cycloalkyl;
• ring A is selected from formula (i) to (viii), wherein the substituent R3 on ring A may be substituted on any of the ring C atoms,
• Rc and Rd are substituted or unsubstituted alkyl or together with the carbon atoms to which Rc and Rd are attached form a C3-C6 cycloalkyl ring;
• Hy is selected from formula (a-1) to (d-1),
• R is selected from —NR4R5, substituted or unsubstituted alkyl and cycloalkyl;
• R1 and R2 together with the carbon atoms to which they are attached form a bond in order to form a —C═C—;
• or R1 and R2 together with the carbon atoms to which they are attached form a cyclopropane ring;
• R2′ and R2a which may be same or different and are independently selected at each occurrence from hydrogen and substituted or unsubstituted alkyl;
• R3 is independently selected at each occurrence from halogen, cyano, nitro, substituted or unsubstituted alkyl, —OR6, —NR7R8, substituted or unsubstituted cycloalkyl, —C(O)OH, —C(O)O-alkyl, —C(O)R9, —C(O)NR7R8, —NR7C(O)R9, substituted or unsubstituted aryl, substituted or unsubstituted heteroaryl, substituted or unsubstituted heterocyclyl and haloalkyl;
• R4 and R5 are independently selected from hydrogen, substituted or unsubstituted alkyl, and substituted or unsubstituted cycloalkyl;
• R6 is selected from hydrogen, substituted or unsubstituted alkyl, and substituted or unsubstituted cycloalkyl;
• R7 and R8 are independently selected from hydrogen, substituted or unsubstituted alkyl, and substituted or unsubstituted cycloalkyl;
• R9 is selected from substituted or unsubstituted alkyl and substituted or unsubstituted cycloalkyl;
• R10 is selected from hydrogen, halogen, and substituted or unsubstituted alkyl;
• ‘m’ is an integer ranging from 0 to 1, both inclusive;
• ‘n’ is an integer ranging from 0 to 4, both inclusive;
• when an alkyl group is substituted, it is substituted with 1 to 4 substituents independently selected from oxo (═O), halogen, cyano, cycloalkyl, aryl, heteroaryl, heterocyclyl, —OR7a, —C(═O)OH, —C(═O)O (alkyl), —NR8aR8b, —NR8aC(═O)R9a, and —C(═O)NR8aR8b;
• when the heteroaryl group is substituted, it is substituted with 1 to 4 substituents independently selected from halogen, cyano, alkyl, haloalkyl, perhaloalkyl, cycloalkyl, heterocyclyl, —OR7a, —NR8aR8b—NR7aC(═O)R9a, —C(═O)NR8aR8b;
• when the aryl group is substituted, it is substituted with 1 to 4 substituents independently selected from halogen, cyano, alkyl, haloalkyl, perhaloalkyl, cycloalkyl, heterocyclyl, —OR7a, —NR8aR8b—NR7aC(═O)R9a, —C(═O)NR8aR8b;
• when the cycloalkyl group is substituted, it is substituted with 1 to 4 substituents independently selected from halogen, cyano, alkyl, haloalkyl, perhaloalkyl, —OR7a, —NR8aR8b, —NR7aC(═O)R9a, —C(═O)NR8aR8b;
• R7a is selected from hydrogen, alkyl, perhaloalkyl, and cycloalkyl;
• R8a and R8b are each independently selected from hydrogen, alkyl, and cycloalkyl;
• and
• R9a is selected from alkyl and cycloalkyl.