Compositions and methods for modulating inflammation and wound healing

A method for improving wound healing after a skin procedure or surgical procedure in a subject, the method comprising:

• (a) applying to a skin region of the subject a first topical composition comprising a tripeptide-1 and hexapeptide-12 before the skin procedure or the surgical procedure;
• and
• (b) applying to the skin region of the subject a second topical composition comprising tripeptide-1, a hexapeptide-12, and a hexapeptide-11,
• wherein the first topical composition, the second topical composition, or both, is administered in an amount sufficient to modulate an expression level of one or more inflammatory or regenerative genes.