Methods for preventing and reversing opioid analgesic tolerance in subjects with chronic pain

A method for preventing and/or reducing opioid analgesic tolerance in a subject treated for chronic pain comprising:

• administering to the subject an effective amount of a non-receptor tyrosine kinase (c-Src) inhibitor, wherein the subject has chronic pain and is administered chronic opioid analgesic therapy prior to or concurrently with the administration of the c-Src inhibitor, and
• wherein said administration of the c-Src inhibitor prevents or reduces opioid analgesic tolerance in the subject.

A method for preventing and/or reducing opioid analgesic tolerance in a subject treated for chronic pain comprising:

• administering to the subject an effective amount of:
• a caveolin-1 scaffolding domain (CSD) polypeptide and a non-receptor tyrosine kinase (c-Src) inhibitor, wherein the subject has chronic pain and is administered chronic opioid analgesic therapy prior to or concurrently with the administration of the CSD polypeptide and the c-Src inhibitor, and wherein said administration of the CSD polypeptide and the c-Src inhibitor prevents or reduces opioid analgesic tolerance in the subject.