Tricyclic compounds with oma1/opa1 modulatory properties
Assignee712 North Inc.
InventorMarcel Victor Alavi Khorassani Moghadam
Life of this patent
Estimating the term…
Abstract
Tricyclic compounds, and in particular novel dibenzoxazepin derivates are disclosed herein, which were quite surprisingly found as having OMA1 and/or OPA1 modulatory properties. Compounds of present invention may provide useful for the treatment of certain conditions and diseases, which are amenable to OMA1 and/or OPA1-modulatory therapies. Such conditions may include conditions and diseases prevalent in the elderly, including cancer. Pharmaceutical compositions comprising compounds of present invention may be combined with other treatments or further comprise other pharmaceutically active ingredients.
Claims23
A compound of formula (I)
- or any stereochemically isomeric form thereof, wherein A, B, and R1 to R10 represent an atom or a group, and wherein at least one of R1, R2, R3, R4, R7, R8, R9, or R10 is a group of formula (II)
- or any stereochemically isomeric form thereof, wherein A′, R′1 and R′2 represent an atom or a group, and B′ represent an atom, or a pharmaceutically acceptable salt thereof, or an N-oxide thereof.
(canceled)
-15. (canceled)
-20. (canceled)
The pharmaceutical composition of claim 9, wherein the cancer drug is temozolomide or a derivate or a prodrug or a pharmaceutical acceptable salt thereof.
The pharmaceutical composition of claim 9, wherein the cancer drug is sorafenib or a derivate or a prodrug or a pharmaceutical acceptable salt thereof.
The method of claim 14, wherein the subject is diagnosed with OMA1 alterations.
The method of claim 14, wherein the subject has cancer.
The method of claim 14, wherein the subject has a brain tumor.
The method of claim 14, wherein the subject has glioma.
The method of claim 14, wherein the subject has glioblastoma.
The method of claim 14, wherein the compound is administered orally, sublingually, intravenously, intrasternally, transdermally, subcutaneously, intramuscularly, topically, rectally, vaginally, nasally or via the trigeminal nerve.
Dependencies are inferred from the claim text.