Cyclin-dependent kinase inhibitors

A compound or a pharmaceutically acceptable salt thereof comprising Formulae III-VIII:

• wherein:
• A is C or N;
• X and Y are independently N, C, or C—F;
• is
• X=Y=H;
• X=Cl, F, Me, OMe, Y=H:
• X=Y=Cl, F, Me, OMe, where Z is H, Me, or CH2CH2OH;
• and n is 0, 1, 2, or 3;
• R is (CH2)n,
• where Rx is H or Me, Ry is Me, OH, or OMe;
• Rz is H, Me, OMe, OH, N, F, or CF3;
• and n is 1 to 11;
• and
• R1 is:
• where R3 is H, Me, isopropyl, isobutyl, CH2CH2OH, or bicyclo[1.1.1]pentane;
• R4 is H, Me, OMe, CF3, or CHF2;
• R5 is H or Me;
• X is C—H, N, or C—F;
• Y is H, N, F, Me, OMe, CF3, or CHF2;
• Q is O or S;
• n is 1, 2, or 3;
• and
• where T is O, NH, NMe, N-isopropyl, or N-isobutyl.

A compound or a pharmaceutically acceptable salt thereof comprising Formulae IX-XX:

• where Z is H, Me, or CH2CH2OH, and n is 0, 1, 2, or 3;
• R is (CH2)n,
• where Rx is H or Me, Ry is Me, OH, or OMe;
• Rz is H, Me, OMe, OH, N, F, or CF3;
• and n is 1 to 11;
• and
• R1 is
• where R3 is H, Me, isopropyl, isobutyl, CH2CH2OH, or bicyclo[1.1.1]pentane;
• R4 is H, Me, OMe, CF3, or CHF2;
• R5 is H or Me;
• X is C—H, N, or C—F;
• Y is H, N, F, Me, OMe, CF3, or CHF2;
• Q is O or S;
• n is 1, 2, or 3;
• and
• R2 is:
• where T is O, NH, NMe, N-isopropyl, or N-isobutyl.

A compound selected from:

• 7′-cyclopentyl-1-methyl-2′-((4-(4-methylpiperazin-1-yl)phenyl)amino)-5′,7′-dihydrospiro[pyrrolidine-3,6′-pyrrolo[2,3-d]pyrimidin]-2-one (C1);
• 7′-cyclopentyl-1-methyl-2′-((4-(piperazin-1-yl)phenyl)amino)-5′,7′-dihydrospiro[pyrrolidine-3,6′-pyrrolo[2,3-d]pyrimidin]-2-one (C2);
• 7′-cyclopentyl-2′-((5-(4-isopropylpiperazin-1-yl)pyridin-2-yl)amino)-1-methyl-5′,7′-dihydrospiro[pyrrolidine-3,6′-pyrrolo[2,3-d]pyrimidin]-2-one (C3);
• 7′-cyclopentyl-2′-((5-(2-(dimethylamino)ethoxy)pyridin-2-yl)amino)-1-methyl-5′,7′-dihydrospiro[pyrrolidine-3,6′-pyrrolo[2,3-d]pyrimidin]-2-one (C4);
• 7′-cyclopentyl-1-methyl-2′-((5-(2-(pyrrolidin-1-yl)ethoxy)pyridin-2-yl)amino)-5′,7′-dihydrospiro[pyrrolidine-3,6′-pyrrolo[2,3-d]pyrimidin]-2-one (C5);
• 7′-cyclopentyl-1-methyl-2′-((5-(2-(piperidin-1-yl)ethoxy)pyridin-2-yl)amino)-5′,7′-dihydrospiro[pyrrolidine-3,6′-pyrrolo[2,3-d]pyrimidin]-2-one (C6);
• 7′-cyclopentyl-1-methyl-2′-((4-(4-methylpiperazin-1-yl)phenyl)amino)-5′,7′-dihydrospiro[piperidine-3,6′-pyrrolo[2,3-d]pyrimidin]-2-one (C7);
• 7′-cyclopentyl-1-methyl-2′-((4-(piperazin-1-yl)phenyl)amino)-5′,7′-dihydrospiro[piperidine-3,6′-pyrrolo[2,3-d]pyrimidin]-2-one (C8);
• 7′-cyclopentyl-2′-((5-(4-isopropylpiperazin-1-yl)pyridin-2-yl)amino)-1-methyl-5′,7′-dihydrospiro[piperidine-3,6′-pyrrolo[2,3-d]pyrimidin]-2-one (C9);
• 7′-cyclopentyl-1-methyl-2′-((5-(2-(pyrrolidin-1-yl)ethoxy)pyridin-2-yl)amino)-5′,7′-dihydrospiro[piperidine-3,6′-pyrrolo[2,3-d]pyrimidin]-2-one (C10);
• 7′-cyclopentyl-1-methyl-2′-((5-(2-(piperidin-1-yl)ethoxy)pyridin-2-yl)amino)-5′,7′-dihydrospiro[piperidine-3,6′-pyrrolo[2,3-d]pyrimidin]-2-one (C11);
• 7′-cyclopentyl-1-(4-methoxybenzyl)-2′-((4-(4-methylpiperazin-1-yl)phenyl)amino)-5′,7′-dihydrospiro[pyrrolidine-3,6′-pyrrolo[2,3-d]pyrimidin]-2-one (C12);
• 7′-cyclopentyl-1-methyl-2′-((5-(4-methylpiperazin-1-yl)-4-(trifluoromethyl)pyridin-2-yl)amino)-5′,7′-dihydrospiro[pyrrolidine-3,6′-pyrrolo[2,3-d]pyrimidin]-2-one (C13);
• 7′-cyclopentyl-1-methyl-2′-((5-(piperazin-1-yl)-4-(trifluoromethyl)pyridin-2-yl)amino)-5′,7′-dihydrospiro[piperidine-3,6′-pyrrolo[2,3-d]pyrimidin]-2-one (C14);
• 7′-cyclopentyl-1-methyl-2′-((5-(piperazin-1-yl)-4-(trifluoromethyl)pyridin-2-yl)amino)-5′,7′-dihydrospiro[pyrrolidine-3,6′-pyrrolo[2,3-d]pyrimidin]-2-one (C15);
• 7′-cyclopentyl-1-(4-methoxybenzyl)-2′-((5-(piperazin-1-yl)-4-(trifluoromethyl)pyridin-2-yl)amino)-5′,7′-dihydrospiro[pyrrolidine-3,6′-pyrrolo[2,3-d]pyrimidin]-2-one (C16);
• 7′-cyclopentyl-2′-((5-(piperazin-1-yl)-4-(trifluoromethyl)pyridin-2-yl)amino)-5′,7′-dihydrospiro[pyrrolidine-3,6′-pyrrolo[2,3-d]pyrimidin]-2-one (C17);
• 7′-cyclopentyl-2′-((5-(4-methylpiperazin-1-yl)-4-(trifluoromethyl)pyridin-2-yl)amino)-5′,7′-dihydrospiro[pyrrolidine-3,6′-pyrrolo[2,3-d]pyrimidin]-2-one (C18);
• 7′-cyclopentyl-1-methyl-2′-((5-(piperazin-1-yl)pyridin-2-yl)amino)-5′,7′-dihydrospiro[pyrrolidine-3,6′-pyrrolo[2,3-d]pyrimidin]-2-one (C19);
• 7′-cyclopentyl-1-methyl-2′-((5-(4-methylpiperazin-1-yl)pyridin-2-yl)amino)-5′,7′-dihydrospiro[pyrrolidine-3,6′-pyrrolo[2,3-d]pyrimidin]-2-one (C20);
• 1-benzyl-7′-cyclopentyl-2′-((5-(piperazin-1-yl)pyridin-2-yl)amino)-5′,7′-dihydrospiro[pyrrolidine-3,6′-pyrrolo[2,3-d]pyrimidin]-2-one (C21);
• 1-benzyl-7′-cyclopentyl-2′-((5-(4-methylpiperazin-1-yl)pyridin-2-yl)amino)-5′,7′-dihydrospiro[pyrrolidine-3,6′-pyrrolo[2,3-d]pyrimidin]-2-one (C22);
• 1-benzyl-7′-cyclopentyl-2′-((5-(4-isopropylpiperazin-1-yl)pyridin-2-yl)amino)-5′,7′-dihydrospiro[pyrrolidine-3,6′-pyrrolo[2,3-d]pyrimidin]-2-one (C23);
• 1-benzyl-7′-cyclopentyl-2′-((4-(4-methylpiperazin-1-yl)phenyl)amino)-5′,7′-dihydrospiro[pyrrolidine-3,6′-pyrrolo[2,3-d]pyrimidin]-2-one (C24);
• 7′-cyclopentyl-1-methyl-2′-((5-(piperazin-1-yl)pyridin-2-yl)amino)-5′,7′-dihydrospiro[piperidine-3,6′-pyrrolo[2,3-d]pyrimidin]-2-one (C25);
• 7′-cyclopentyl-1-methyl-2′-((5-(4-methylpiperazin-1-yl)pyridin-2-yl)amino)-5′,7′-dihydrospiro[piperidine-3,6′-pyrrolo[2,3-d]pyrimidin]-2-one (C26);
• 1-benzyl-7′-cyclopentyl-2′-((5-(piperazin-1-yl)pyridin-2-yl)amino)-5′,7′-dihydrospiro[piperidine-3,6′-pyrrolo[2,3-d]pyrimidin]-2-one (C27);
• 1-benzyl-7′-cyclopentyl-2′-((5-(4-methylpiperazin-1-yl)pyridin-2-yl)amino)-5′,7′-dihydrospiro[piperidine-3,6′-pyrrolo[2,3-d]pyrimidin]-2-one (C28);
• 7′-cyclopentyl-1-(4-methoxybenzyl)-2′-((5-(piperazin-1-yl)pyridin-2-yl)amino)-5′,7′-dihydrospiro[pyrrolidine-3,6′-pyrrolo[2,3-d]pyrimidin]-2-one (C29);
• 7′-cyclopentyl-1-(4-methoxybenzyl)-2′-((5-(4-methylpiperazin-1-yl)pyridin-2-yl)amino)-5′,7′-dihydrospiro[pyrrolidine-3,6′-pyrrolo[2,3-d]pyrimidin]-2-one (C30);
• 7′-cyclopentyl-2′-((5-(4-isopropylpiperazin-1-yl)pyridin-2-yl)amino)-1-(4-methoxybenzyl)-5′,7′-dihydrospiro[pyrrolidine-3,6′-pyrrolo[2,3-d]pyrimidin]-2-one (C31);
• 7′-cyclopentyl-2′-((5-(2-(dimethylamino)ethoxy)pyridin-2-yl)amino)-1-(4-methoxybenzyl)-5′,7′-dihydrospiro[pyrrolidine-3,6′-pyrrolo[2,3-d]pyrimidin]-2-one (C32);
• 7′-cyclopentyl-2′-((5-(piperazin-1-yl)pyridin-2-yl)amino)-5′,7′-dihydrospiro[pyrrolidine-3,6′-pyrrolo[2,3-d]pyrimidin]-2-one (C33);
• 7′-cyclopentyl-2′-((5-(4-methylpiperazin-1-yl)pyridin-2-yl)amino)-5′,7′-dihydrospiro[pyrrolidine-3,6′-pyrrolo[2,3-d]pyrimidin]-2-one (C34);
• 7′-cyclopentyl-2′-((5-(piperazin-1-yl)pyridin-2-yl)amino)-5′,7′-dihydrospiro[piperidine-3,6′-pyrrolo[2,3-d]pyrimidin]-2-one (C35);
• 7′-cyclopentyl-2′-((5-(4-methylpiperazin-1-yl)pyridin-2-yl)amino)-5′,7′-dihydrospiro[piperidine-3,6′-pyrrolo[2,3-d]pyrimidin]-2-one (C36);
• 7′-cyclopentyl-2′-((5-(4-isopropylpiperazin-1-yl)pyridin-2-yl)amino)-5′,7′-dihydrospiro[piperidine-3,6′-pyrrolo[2,3-d]pyrimidin]-2-one (C37);
• 7′-cyclopentyl-2′-((5-(4-isopropylpiperazin-1-yl)pyridin-2-yl)amino)-5′,7′-dihydrospiro[pyrrolidine-3,6′-pyrrolo[2,3-d]pyrimidin]-2-one (C38);
• 1-benzyl-7′-cyclopentyl-2′-((3-fluoro-4-(4-methylpiperazin-1-yl)phenyl)amino)-5′,7′-dihydrospiro[pyrrolidine-3,6′-pyrrolo[2,3-d]pyrimidin]-2-one (C39);
• 1-benzyl-7′-cyclopentyl-2′-((3-fluoro-4-(4-methylpiperazin-1-yl)phenyl)amino)-5′,7′-dihydrospiro[piperidine-3,6′-pyrrolo[2,3-d]pyrimidin]-2-one (C40);
• 1-benzyl-7′-cyclopentyl-2′-((2-fluoro-4-(4-methylpiperazin-1-yl)phenyl)amino)-5′,7′-dihydrospiro[pyrrolidine-3,6′-pyrrolo[2,3-d]pyrimidin]-2-one (C41);
• 1-benzyl-7′-cyclopentyl-2′-((2-fluoro-4-(4-methylpiperazin-1-yl)phenyl)amino)-5′,7′-dihydrospiro[piperidine-3,6′-pyrrolo[2,3-d]pyrimidin]-2-one (C42);
• 7′-cyclopentyl-2′-((4-(piperazin-1-yl)phenyl)amino)-5′,7′-dihydrospiro[pyrrolidine-3,6′-pyrrolo[2,3-d]pyrimidin]-2-one (C43);
• 7′-cyclopentyl-2′-((5-(piperazin-1-yl)-4-(trifluoromethyl)pyridin-2-yl)amino)-5′,7′-dihydrospiro[piperidine-3,6′-pyrrolo[2,3-d]pyrimidin]-2-one (C44);
• 7′-cyclopentyl-2′-((4-(4-methylpiperazin-1-yl)phenyl)amino)-5′,7′-dihydrospiro[pyrrolidine-3,6′-pyrrolo[2,3-d]pyrimidin]-2-one (C45);
• 7′-cyclopentyl-2′-((4-(4-isopropylpiperazin-1-yl)phenyl)amino)-5′,7′-dihydrospiro[pyrrolidine-3,6′-pyrrolo[2,3-d]pyrimidin]-2-one (C46);
• 7′-cyclopentyl-2′-((3-fluoro-4-(piperazin-1-yl)phenyl)amino)-5′,7′-dihydrospiro[pyrrolidine-3,6′-pyrrolo[2,3-d]pyrimidin]-2-one (C47);
• 7′-cyclopentyl-2′-((3-fluoro-4-(4-methylpiperazin-1-yl)phenyl)amino)-5′,7′-dihydrospiro[pyrrolidine-3,6′-pyrrolo[2,3-d]pyrimidin]-2-one (C48);
• 7′-cyclopentyl-2′-((3-fluoro-4-(4-isopropylpiperazin-1-yl)phenyl)amino)-5′,7′-dihydrospiro[pyrrolidine-3,6′-pyrrolo[2,3-d]pyrimidin]-2-one (C49);
• 7′-cyclopentyl-2′-((2-fluoro-4-(piperazin-1-yl)phenyl)amino)-5′,7′-dihydrospiro[pyrrolidine-3,6′-pyrrolo[2,3-d]pyrimidin]-2-one (C50);
• 7′-cyclopentyl-2′-((2-fluoro-4-(4-methylpiperazin-1-yl)phenyl)amino)-5′,7′-dihydrospiro[pyrrolidine-3,6′-pyrrolo[2,3-d]pyrimidin]-2-one (C51);
• 7′-cyclopentyl-2′-((2-fluoro-4-(4-isopropylpiperazin-1-yl)phenyl)amino)-5′,7′-dihydrospiro[pyrrolidine-3,6′-pyrrolo[2,3-d]pyrimidin]-2-one (C52);
• 7′-cyclopentyl-2′-((6-(piperazin-1-yl)pyridin-3-yl)amino)-5′,7′-dihydrospiro[pyrrolidine-3,6′-pyrrolo[2,3-d]pyrimidin]-2-one (C53);
• 7′-cyclopentyl-2′-((6-(4-methylpiperazin-1-yl)pyridin-3-yl)amino)-5′,7′-dihydrospiro[pyrrolidine-3,6′-pyrrolo[2,3-d]pyrimidin]-2-one (C54);
• 7′-cyclopentyl-2′-((6-(4-isopropylpiperazin-1-yl)pyridin-3-yl)amino)-5′,7′-dihydrospiro[pyrrolidine-3,6′-pyrrolo[2,3-d]pyrimidin]-2-one (C55);
• 7′-cyclopentyl-2′-((1′,2′,3′,6′-tetrahydro-[3,4′-bipyridin]-6-yl)amino)-5′,7′-dihydrospiro[pyrrolidine-3,6′-pyrrolo[2,3-d]pyrimidin]-2-one (C56);
• 7′-cyclopentyl-2′-((1′-isopropyl-1′,2′,3′,6′-tetrahydro-[3,4′-bipyridin]-6-yl)amino)-5′,7′-dihydrospiro[pyrrolidine-3,6′-pyrrolo[2,3-d]pyrimidin]-2-one (C57);
• 7′-cyclopentyl-2′-((3-fluoro-4-morpholinophenyl)amino)-5′,7′-dihydrospiro[pyrrolidine-3,6′-pyrrolo[2,3-d]pyrimidin]-2-one (C58);
• 7′-cyclopentyl-2′-((4-(2-(dimethylamino)ethoxy)phenyl)amino)-5′,7′-dihydrospiro[pyrrolidine-3,6′-pyrrolo[2,3-d]pyrimidin]-2-one (C59);
• 7′-cyclopentyl-2′-((5-(2-(dimethylamino)ethoxy)pyridin-2-yl)amino)-5′,7′-dihydrospiro[pyrrolidine-3,6′-pyrrolo[2,3-d]pyrimidin]-2-one (C60);
• 7′-cyclopentyl-2′-((6-(2-(dimethylamino)ethoxy)pyridin-3-yl)amino)-5′,7′-dihydrospiro[pyrrolidine-3,6′-pyrrolo[2,3-d]pyrimidin]-2-one (C61);
• 7′-cyclopentyl-2′-((4-(4-isopropylpiperazin-1-yl)-3-methoxyphenyl)amino)-5′,7′-dihydrospiro[pyrrolidine-3,6′-pyrrolo[2,3-d]pyrimidin]-2-one (C62);
• 7′-cyclopentyl-2′-((4-(4-isopropylpiperazin-1-yl)-3-methylphenyl)amino)-5′,7′-dihydrospiro[pyrrolidine-3,6′-pyrrolo[2,3-d]pyrimidin]-2-one (C63);
• 2-((5-(4-cyanopiperazin-1-yl)pyridin-2-yl)amino)-7-cyclopentyl-N,N-dimethyl-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide (C64);
• 7′-cyclopentyl-1-methyl-2′-((5-(piperazin-1-yl)pyridin-2-yl)amino)-5′,7′-dihydrospiro[pyrrolidine-3,6′-pyrrolo[2,3-d]pyrimidine]-2,5-dione (C65);
• 7′-cyclopentyl-1-methyl-2′-((5-(4-methylpiperazin-1-yl)pyridin-2-yl)amino)-5′,7′-dihydrospiro[pyrrolidine-3,6′-pyrrolo[2,3-d]pyrimidine]-2,5-dione (C66);
• 7′-cyclopentyl-2′-((5-(4-isopropylpiperazin-1-yl)pyridin-2-yl)amino)-1-methyl-5′,7′-dihydrospiro[pyrrolidine-3,6′-pyrrolo[2,3-d]pyrimidine]-2,5-dione (C67);
• 7′-cyclopentyl-1-methyl-2′-((4-(piperazin-1-yl)phenyl)amino)-5′,7′-dihydrospiro[pyrrolidine-3,6′-pyrrolo[2,3-d]pyrimidine]-2,5-dione (C68);
• 7′-cyclopentyl-1-methyl-2′-((4-(4-methylpiperazin-1-yl)phenyl)amino)-5′,7′-dihydrospiro[pyrrolidine-3,6′-pyrrolo[2,3-d]pyrimidine]-2,5-dione (C69);
• 7′-cyclopentyl-2′-((4-(4-isopropylpiperazin-1-yl)phenyl)amino)-1-methyl-5′,7′-dihydrospiro[pyrrolidine-3,6′-pyrrolo[2,3-d]pyrimidine]-2,5-dione (C70);
• 7′-cyclopentyl-2′-((3-fluoro-4-(piperazin-1-yl)phenyl)amino)-1-methyl-5′,7′-dihydrospiro[pyrrolidine-3,6′-pyrrolo[2,3-d]pyrimidine]-2,5-dione (C72);
• 7′-cyclopentyl-2′-((3-fluoro-4-(4-methylpiperazin-1-yl)phenyl)amino)-1-methyl-5′,7′-dihydrospiro[pyrrolidine-3,6′-pyrrolo[2,3-d]pyrimidine]-2,5-dione (C72);
• 7′-cyclopentyl-2′-((3-fluoro-4-(4-isopropylpiperazin-1-yl)phenyl)amino)-1-methyl-5′,7′-dihydrospiro[pyrrolidine-3,6′-pyrrolo[2,3-d]pyrimidine]-2,5-dione (C73);
• 7′-cyclopentyl-2′-((5-(piperazin-1-yl)pyridin-2-yl)amino)-5′,7′-dihydrospiro[pyrrolidine-3,6′-pyrrolo[2,3-d]pyrimidine]-2,5-dione (C74);
• 7′-cyclopentyl-2′-((5-(4-methylpiperazin-1-yl)pyridin-2-yl)amino)-5′,7′-dihydrospiro[pyrrolidine-3,6′-pyrrolo[2,3-d]pyrimidine]-2,5-dione (C75);
• 7′-cyclopentyl-2′-((5-(4-isopropylpiperazin-1-yl)pyridin-2-yl)amino)-5′,7′-dihydrospiro[pyrrolidine-3,6′-pyrrolo[2,3-d]pyrimidine]-2,5-dione (C76);
• 7′-cyclopentyl-2′-((4-(piperazin-1-yl)phenyl)amino)-5′,7′-dihydrospiro[pyrrolidine-3,6′-pyrrolo[2,3-d]pyrimidine]-2,5-dione (C77);
• 7′-cyclopentyl-2′-((4-(4-methylpiperazin-1-yl)phenyl)amino)-5′,7′-dihydrospiro[pyrrolidine-3,6′-pyrrolo[2,3-d]pyrimidine]-2,5-dione (C78);
• 7′-cyclopentyl-2′-((4-(4-isopropylpiperazin-1-yl)phenyl)amino)-5′,7′-dihydrospiro[pyrrolidine-3,6′-pyrrolo[2,3-d]pyrimidine]-2,5-dione (C79);
• 7′-cyclopentyl-2′-((3-fluoro-4-(piperazin-1-yl)phenyl)amino)-5′,7′-dihydrospiro[pyrrolidine-3,6′-pyrrolo[2,3-d]pyrimidine]-2,5-dione (C80);
• 7′-cyclopentyl-2′-((3-fluoro-4-(4-methylpiperazin-1-yl)phenyl)amino)-5′,7′-dihydrospiro[pyrrolidine-3,6′-pyrrolo[2,3-d]pyrimidine]-2,5-dione (C81);
• 7′-cyclopentyl-2′-((3-fluoro-4-(4-isopropylpiperazin-1-yl)phenyl)amino)-5′,7′-dihydrospiro[pyrrolidine-3,6′-pyrrolo[2,3-d]pyrimidine]-2,5-dione (C82);
• 7′-cyclopentyl-2′-((6-(piperazin-1-yl)pyridin-3-yl)amino)-5′,7′-dihydrospiro[pyrrolidine-3,6′-pyrrolo[2,3-d]pyrimidine]-2,5-dione (C83);
• 7′-cyclopentyl-2′-((6-(4-methylpiperazin-1-yl)pyridin-3-yl)amino)-5′,7′-dihydrospiro[pyrrolidine-3,6′-pyrrolo[2,3-d]pyrimidine]-2,5-dione (C84);
• 7′-cyclopentyl-2′-((6-(4-isopropylpiperazin-1-yl)pyridin-3-yl)amino)-5′,7′-dihydrospiro[pyrrolidine-3,6′-pyrrolo[2,3-d]pyrimidine]-2,5-dione (C85);
• 7′-cyclopentyl-2′-((3-fluoro-4-morpholinophenyl)amino)-5′,7′-dihydrospiro[pyrrolidine-3,6′-pyrrolo[2,3-d]pyrimidine]-2,5-dione (C86);
• 7′-cyclopentyl-2′-((2-fluoro-4-(4-methylpiperazin-1-yl)phenyl)amino)-5′,7′-dihydrospiro[pyrrolidine-3,6′-pyrrolo[2,3-d]pyrimidine]-2,5-dione (C87);
• 7′-cyclopentyl-2′-((6-(2-(dimethylamino)ethoxy)pyridin-3-yl)amino)-5′,7′-dihydrospiro[pyrrolidine-3,6′-pyrrolo[2,3-d]pyrimidine]-2,5-dione (C88);
• 7′-cyclopentyl-2′-((4-(2-(dimethylamino)ethoxy)phenyl)amino)-5′,7′-dihydrospiro[pyrrolidine-3,6′-pyrrolo[2,3-d]pyrimidine]-2,5-dione (C89);
• 7′-cyclopentyl-2′-((6-(2-(pyrrolidin-1-yl)ethoxy)pyridin-3-yl)amino)-5′,7′-dihydrospiro[pyrrolidine-3,6′-pyrrolo[2,3-d]pyrimidine]-2,5-dione (C90);
• 7′-cyclopentyl-2′-((3-fluoro-4-(2-(pyrrolidin-1-yl)ethoxy)phenyl)amino)-5′,7′-dihydrospiro[pyrrolidine-3,6′-pyrrolo[2,3-d]pyrimidine]-2,5-dione (C91);
• 7′-cyclopentyl-2′-((5-(2-(dimethylamino)ethoxy)pyridin-2-yl)amino)-5′,7′-dihydrospiro[pyrrolidine-3,6′-pyrrolo[2,3-d]pyrimidine]-2,5-dione (C92);
• 7′-cyclopentyl-2′-((1′,2′,3′,6′-tetrahydro-[3,4′-bipyridin]-6-yl)amino)-5′,7′-dihydrospiro[pyrrolidine-3,6′-pyrrolo[2,3-d]pyrimidine]-2,5-dione (C93);
• 7′-cyclopentyl-2′-((1′-isopropyl-1′,2′,3′,6′-tetrahydro-[3,4′-bipyridin]-6-yl)amino)-5′,7′-dihydrospiro[pyrrolidine-3,6′-pyrrolo[2,3-d]pyrimidine]-2,5-dione (C94);
• 7′-cyclopentyl-2′-((4-(4-morpholinopiperidin-1-yl)phenyl)amino)-5′,7′-dihydrospiro[pyrrolidine-3,6′-pyrrolo[2,3-d]pyrimidin]-2-one (C95);
• 7′-cyclopentyl-2′-((6-(4-morpholinopiperidin-1-yl)pyridin-3-yl)amino)-5′,7′-dihydrospiro[pyrrolidine-3,6′-pyrrolo[2,3-d]pyrimidin]-2-one (C96);
• 7′-cyclopentyl-2′-((3-fluoro-4-(4-morpholinopiperidin-1-yl)phenyl)amino)-5′,7′-dihydrospiro[pyrrolidine-3,6′-pyrrolo[2,3-d]pyrimidin]-2-one (C97);
• 7′-cyclopentyl-2′-((5-(4-methylpiperazin-1-yl)pyridin-2-yl)amino)-6′,7′-dihydrospiro[pyrrolidine-3,5′-pyrrolo[2,3-d]pyrimidin]-2-one (C98);
• 7′-cyclopentyl-2′-((5-(piperazin-1-yl)pyridin-2-yl)amino)spiro[pyrrolidine-3,5′-pyrrolo[2,3-d]pyrimidine]-2,6′(7′H)-dione (C99);
• 7′-cyclopentyl-2′-((5-(4-methylpiperazin-1-yl)pyridin-2-yl)amino)spiro[pyrrolidine-3,5′-pyrrolo[2,3-d]pyrimidine]-2,6′(7′H)-dione (C100);
• 7′-cyclopentyl-2′-((4-(4-methylpiperazin-1-yl)phenyl)amino)spiro[pyrrolidine-3,5′-pyrrolo[2,3-d]pyrimidine]-2,6′(7′H)-dione (C101);
• 7′-cyclopentyl-2′-((3-fluoro-4-(piperazin-1-yl)phenyl)amino)spiro[pyrrolidine-3,5′-pyrrolo[2,3-d]pyrimidine]-2,6′(7′H)-dione (C102);
• 7′-cyclopentyl-2′-((3-fluoro-4-(4-methylpiperazin-1-yl)phenyl)amino)spiro[pyrrolidine-3,5′-pyrrolo[2,3-d]pyrimidine]-2,6′(7′H)-dione (C103);
• 7′-cyclopentyl-2′-((3-fluoro-4-(4-isopropylpiperazin-1-yl)phenyl)amino)spiro[pyrrolidine-3,5′-pyrrolo[2,3-d]pyrimidine]-2,6′(7′H)-dione (C104);
• 7′-cyclopentyl-2′-((4-((S)-3-(dimethylamino)pyrrolidin-1-yl)-3-fluorophenyl)amino)spiro[pyrrolidine-3,5′-pyrrolo[2,3-d]pyrimidine]-2,6′(7′H)-dione (C105);
• 7′-cyclopentyl-2′-((3-fluoro-4-(4-morpholinopiperidin-1-yl)phenyl)amino)spiro[pyrrolidine-3,5′-pyrrolo[2,3-d]pyrimidine]-2,6′(7′H)-dione (C106);
• 7′-cyclopentyl-2′-((3-fluoro-4-(2,6-diazaspiro[3.3]heptan-2-yl)phenyl)amino)-5′,7′-dihydrospiro[pyrrolidine-3,6′-pyrrolo[2,3-d]pyrimidin]-2-one (C107);
• 7′-cyclopentyl-2′-((4-(2-(dimethylamino)ethoxy)phenyl)amino)-5′,7′-dihydrospiro[pyrrolidine-3,6′-pyrrolo[2,3-d]pyrimidin]-2-one (C108);
• 7′-cyclohexyl-2′-((4-(2-(dimethylamino)ethoxy)phenyl)amino)-5′,7′-dihydrospiro[pyrrolidine-3,6′-pyrrolo[2,3-d]pyrimidin]-2-one (C109);
• 7′-cyclopentyl-2′-((6-(2-(dimethylamino)ethoxy)pyridin-3-yl)amino)-5′,7′-dihydrospiro[pyrrolidine-3,6′-pyrrolo[2,3-d]pyrimidin]-2-one (C110);
• 7′-cyclopentyl-2′-((4-(2-(dimethylamino)ethoxy)-3-fluorophenyl)amino)-5′,7′-dihydrospiro[pyrrolidine-3,6′-pyrrolo[2,3-d]pyrimidin]-2-one (C111);
• 7′-cyclopentyl-2′-((4-(2-(dimethylamino)ethoxy)-3-methylphenyl)amino)-5′,7′-dihydrospiro[pyrrolidine-3,6′-pyrrolo[2,3-d]pyrimidin]-2-one (C112);
• 7′-cyclopentyl-2′-((4-(2-(dimethylamino)ethoxy)-3-methoxyphenyl)amino)-5′,7′-dihydrospiro[pyrrolidine-3,6′-pyrrolo[2,3-d]pyrimidin]-2-one (C113);
• 7′-cyclopentyl-2′-((4-(piperazin-1-yl)phenyl)amino)-5′,7′-dihydrospiro[pyrrolidine-3,6′-pyrrolo[2,3-d]pyrimidin]-2-one (C114);
• 7′-cyclopentyl-2′-((4-(4-methylpiperazin-1-yl)phenyl)amino)-5′,7′-dihydrospiro[pyrrolidine-3,6′-pyrrolo[2,3-d]pyrimidin]-2-one (C115);
• 7′-cyclopentyl-2′-((4-(4-isopropylpiperazin-1-yl)phenyl)amino)-5′,7′-dihydrospiro[pyrrolidine-3,6′-pyrrolo[2,3-d]pyrimidin]-2-one (C116);
• 7′-cyclopentyl-2′-((3-fluoro-4-(piperazin-1-yl)phenyl)amino)-5′,7′-dihydrospiro[pyrrolidine-3,6′-pyrrolo[2,3-d]pyrimidin]-2-one (C117);
• 7′-cyclopentyl-2′-((3-fluoro-4-(4-isopropylpiperazin-1-yl)phenyl)amino)-5′,7′-dihydrospiro[pyrrolidine-3,6′-pyrrolo[2,3-d]pyrimidin]-2-one (C118);
• 7′-cyclopentyl-2′-((3-methyl-4-(piperazin-1-yl)phenyl)amino)-5′,7′-dihydrospiro[pyrrolidine-3,6′-pyrrolo[2,3-d]pyrimidin]-2-one (C119);
• 7′-cyclopentyl-2′-((3-methyl-4-(4-methylpiperazin-1-yl)phenyl)amino)-5′,7′-dihydrospiro[pyrrolidine-3,6′-pyrrolo[2,3-d]pyrimidin]-2-one (C120);
• 7′-cyclopentyl-2′-((4-(4-isopropylpiperazin-1-yl)-3-methylphenyl)amino)-5′,7′-dihydrospiro[pyrrolidine-3,6′-pyrrolo[2,3-d]pyrimidin]-2-one (C121);
• 7′-cyclopentyl-2′-((3-methoxy-4-(piperazin-1-yl)phenyl)amino)-5′,7′-dihydrospiro[pyrrolidine-3,6′-pyrrolo[2,3-d]pyrimidin]-2-one (C122);
• 7′-cyclopentyl-2′-((3-methoxy-4-(4-methylpiperazin-1-yl)phenyl)amino)-5′,7′-dihydrospiro[pyrrolidine-3,6′-pyrrolo[2,3-d]pyrimidin]-2-one (C123);
• 7′-cyclopentyl-2′-((4-(4-isopropylpiperazin-1-yl)-3-methoxyphenyl)amino)-5′,7′-dihydrospiro[pyrrolidine-3,6′-pyrrolo[2,3-d]pyrimidin]-2-one (C124);
• 7′-cyclopentyl-2′-((3-fluoro-4-(2,6-diazaspiro[3.3]heptan-2-yl)phenyl)amino)-5′,7′-dihydrospiro[pyrrolidine-3,6′-pyrrolo[2,3-d]pyrimidin]-2-one (C125);
• 2′-((4-(2,6-diazaspiro[3.3]heptan-2-yl)phenyl)amino)-7′-cyclopentyl-5′,7′-dihydrospiro[pyrrolidine-3,6′-pyrrolo[2,3-d]pyrimidin]-2-one (C126);
• 2′-((6-(2,6-diazaspiro[3.3]heptan-2-yl)pyridin-3-yl)amino)-7′-cyclopentyl-5′,7′-dihydrospiro[pyrrolidine-3,6′-pyrrolo[2,3-d]pyrimidin]-2-one (C127);
• 7′-cyclopentyl-2′-((6-(piperazin-1-yl)pyridin-3-yl)amino)-5′,7′-dihydrospiro[pyrrolidine-3,6′-pyrrolo[2,3-d]pyrimidin]-2-one (C128);
• 7′-cyclopentyl-2′-((6-(4-methylpiperazin-1-yl)pyridin-3-yl)amino)-5′,7′-dihydrospiro[pyrrolidine-3,6′-pyrrolo[2,3-d]pyrimidin]-2-one (C129);
• 7′-cyclopentyl-2′-((6-(4-isopropylpiperazin-1-yl)pyridin-3-yl)amino)-5′,7′-dihydrospiro[pyrrolidine-3,6′-pyrrolo[2,3-d]pyrimidin]-2-one (C130);
• 7′-cyclopentyl-2′-((4-(4-morpholinopiperidin-1-yl)phenyl)amino)-5′,7′-dihydrospiro[pyrrolidine-3,6′-pyrrolo[2,3-d]pyrimidin]-2-one (C131);
• 7′-cyclopentyl-2′-((3-fluoro-4-(4-morpholinopiperidin-1-yl)phenyl)amino)-5′,7′-dihydrospiro[pyrrolidine-3,6′-pyrrolo[2,3-d]pyrimidin]-2-one (C132);
• 7′-cyclopentyl-2′-((6-(4-morpholinopiperidin-1-yl)pyridin-3-yl)amino)-5′,7′-dihydrospiro[pyrrolidine-3,6′-pyrrolo[2,3-d]pyrimidin]-2-one (C133);
• 7′-cyclopentyl-2′-((4-(4-isopropylpiperazin-1-yl)phenyl)amino)-5′,7′-dihydrospiro[pyrrolidine-3,6′-pyrrolo[2,3-d]pyrimidine]-2,5-dione (C134);
• 7′-cyclopentyl-2′-((4-(4-isopropylpiperazin-1-yl)phenyl)amino)-5′,7′-dihydrospiro[pyrrolidine-3,6′-pyrrolo[2,3-d]pyrimidine]-2,5-dione (C135);
• 7′-cyclopentyl-2′-((4-(4-methylpiperazin-1-yl)phenyl)amino)-5′,7′-dihydrospiro[pyrrolidine-3,6′-pyrrolo[2,3-d]pyrimidine]-2,5-dione (C136);
• 7′-cyclopentyl-2′-((4-(4-methylpiperazin-1-yl)phenyl)amino)-5′,7′-dihydrospiro[pyrrolidine-3,6′-pyrrolo[2,3-d]pyrimidine]-2,5-dione (C137);
• 7′-cyclopentyl-2′-((4-(piperazin-1-yl)phenyl)amino)-5′,7′-dihydrospiro[pyrrolidine-3,6′-pyrrolo[2,3-d]pyrimidine]-2,5-dione (C138);
• 7′-cyclopentyl-2′-((4-(piperazin-1-yl)phenyl)amino)-5′,7′-dihydrospiro[pyrrolidine-3,6′-pyrrolo[2,3-d]pyrimidine]-2,5-dione (C139);
• 7′-cyclopentyl-2′-((3-fluoro-4-(4-methylpiperazin-1-yl)phenyl)amino)-5′,7′-dihydrospiro[pyrrolidine-3,6′-pyrrolo[2,3-d]pyrimidine]-2,5-dione (C140);
• 7′-cyclopentyl-2′-((3-fluoro-4-(4-methylpiperazin-1-yl)phenyl)amino)-5′,7′-dihydrospiro[pyrrolidine-3,6′-pyrrolo[2,3-d]pyrimidine]-2,5-dione (C141);
• 7′-cyclohexyl-2′-((4-(piperazin-1-yl)phenyl)amino)-5′,7′-dihydrospiro[pyrrolidine-3,6′-pyrrolo[2,3-d]pyrimidin]-2-one (C142);
• 7′-cyclohexyl-2′-((4-(piperazin-1-yl)phenyl)amino)-5′,7′-dihydrospiro[pyrrolidine-3,6′-pyrrolo[2,3-d]pyrimidin]-2-one (C143);
• 7′-cyclohexyl-2′-((4-(4-methylpiperazin-1-yl)phenyl)amino)-5′,7′-dihydrospiro[pyrrolidine-3,6′-pyrrolo[2,3-d]pyrimidin]-2-one (C144);
• 7′-cyclohexyl-2′-((4-(4-methylpiperazin-1-yl)phenyl)amino)-5′,7′-dihydrospiro[pyrrolidine-3,6′-pyrrolo[2,3-d]pyrimidin]-2-one (C145);
• 7′-cyclohexyl-2′-((3-fluoro-4-(4-methylpiperazin-1-yl)phenyl)amino)-5′,7′-dihydrospiro[pyrrolidine-3,6′-pyrrolo[2,3-d]pyrimidin]-2-one (C146);
• 7′-cyclohexyl-2′-((3-fluoro-4-(4-methylpiperazin-1-yl)phenyl)amino)-5′,7′-dihydrospiro[pyrrolidine-3,6′-pyrrolo[2,3-d]pyrimidin]-2-one (C147);
• 7′-cyclopentyl-2′-((4-(6-methyl-2,6-diazaspiro[3.3]heptan-2-yl)phenyl)amino)-5′,7′-dihydrospiro[pyrrolidine-3,6′-pyrrolo[2,3-d]pyrimidine]-2,5-dione (C148);
• 7′-cyclopentyl-2′-((3-fluoro-4-(6-methyl-2,6-diazaspiro[3.3]heptan-2-yl)phenyl)amino)-5′,7′-dihydrospiro[pyrrolidine-3,6′-pyrrolo[2,3-d]pyrimidine]-2,5-dione (C149);
• 7′-cyclopentyl-2′-((4-(6-isopropyl-2,6-diazaspiro[3.3]heptan-2-yl)phenyl)amino)-5′,7′-dihydrospiro[pyrrolidine-3,6′-pyrrolo[2,3-d]pyrimidine]-2,5-dione (C150);
• 7′-cyclopentyl-2′-((3-fluoro-4-(6-isopropyl-2,6-diazaspiro[3.3]heptan-2-yl)phenyl)amino)-5′,7′-dihydrospiro[pyrrolidine-3,6′-pyrrolo[2,3-d]pyrimidine]-2,5-dione (C151);
• 7′-cyclopentyl-2′-((1-(methylsulfonyl)piperidin-4-yl)amino)-5′,7′-dihydrospiro[pyrrolidine-3,6′-pyrrolo[2,3-d]pyrimidine]-2,5-dione (C152);
• 2′-(bicyclo[2.2.1]heptan-2-ylamino)-7′-cyclopentyl-5′,7′-dihydrospiro[pyrrolidine-3,6′-pyrrolo[2,3-d]pyrimidine]-2,5-dione (C153);
• 7′-cyclopentyl-2′-(((1 r,4r)-4-((tetrahydro-2H-pyran-4-yl)amino)cyclohexyl)amino)-5′,7′-dihydrospiro[pyrrolidine-3,6′-pyrrolo[2,3-d]pyrimidine]-2,5-dione (C154);
• 7′-cyclopentyl-2′-((3-fluoro-4-isopropylphenyl)amino)-5′,7′-dihydrospiro[pyrrolidine-3,6′-pyrrolo[2,3-d]pyrimidine]-2,5-dione (C155);
• 7′-cyclopentyl-2′-((4-(6-methyl-2,6-diazaspiro[3.3]heptan-2-yl)phenyl)amino)-5′,7′-dihydrospiro[pyrrolidine-3,6′-pyrrolo[2,3-d]pyrimidin]-2-one (C156);
• 7′-cyclopentyl-2′-((3-fluoro-4-(6-methyl-2,6-diazaspiro[3.3]heptan-2-yl)phenyl)amino)-5′,7′-dihydrospiro[pyrrolidine-3,6′-pyrrolo[2,3-d]pyrimidin]-2-one (C157);
• 7′-cyclopentyl-2′-((4-(6-isopropyl-2,6-diazaspiro[3.3]heptan-2-yl)phenyl)amino)-5′,7′-dihydrospiro[pyrrolidine-3,6′-pyrrolo[2,3-d]pyrimidin]-2-one (C158);
• 7′-cyclopentyl-2′-((3-fluoro-4-(6-isopropyl-2,6-diazaspiro[3.3]heptan-2-yl)phenyl)amino)-5′,7′-dihydrospiro[pyrrolidine-3,6′-pyrrolo[2,3-d]pyrimidin]-2-one (C159);
• 7′-cyclopentyl-2′-((4-(methylsulfonyl)phenyl)amino)-5′,7′-dihydrospiro[pyrrolidine-3,6′-pyrrolo[2,3-d]pyrimidin]-2-one (C160);
• 7′-cyclopentyl-2′-((1-isopropylpiperidin-4-yl)amino)-5′,7′-dihydrospiro[pyrrolidine-3,6′-pyrrolo[2,3-d]pyrimidin]-2-one (C161);
• 7′-cyclopentyl-2′-(((1 r,4r)-4-((tetrahydro-2H-pyran-4-yl)amino)cyclohexyl)amino)-5′,7′-dihydrospiro[pyrrolidine-3,6′-pyrrolo[2,3-d]pyrimidin]-2-one (C162);
• 7′-cyclopentyl-2′-(((1 S,2S)-2-hydroxy-2-methylcyclopentyl)amino)-5′,7′-dihydrospiro[pyrrolidine-3,6′-pyrrolo[2,3-d]pyrimidin]-2-one (C163);
• 7′-cyclopentyl-2′-((4-(1-methylpiperidin-4-yl)phenyl)amino)-5′,7′-dihydrospiro[pyrrolidine-3,6′-pyrrolo[2,3-d]pyrimidin]-2-one (C164);
• 7′-cyclopentyl-2′-((4-(2-morpholinoethoxy)phenyl)amino)-5′,7′-dihydrospiro[pyrrolidine-3,6′-pyrrolo[2,3-d]pyrimidin]-2-one (C165);
• 7′-cyclopentyl-2′-((3-fluoro-4-morpholinophenyl)amino)-5′,7′-dihydrospiro[pyrrolidine-3,6′-pyrrolo[2,3-d]pyrimidin]-2-one (C166);
• 7′-cyclopentyl-2′-((6-(2-(dimethylamino)ethoxy)pyridin-3-yl)amino)-5′,7′-dihydrospiro[pyrrolidine-3,6′-pyrrolo[2,3-d]pyrimidin]-2-one (C167);
• 7′-cyclopentyl-2′-((4-(1-methyl-1H-pyrazol-4-yl)phenyl)amino)-5′,7′-dihydrospiro[pyrrolidine-3,6′-pyrrolo[2,3-d]pyrimidin]-2-one (C168);
• 7′-cyclopentyl-2′-((4-(1-isopropyl-1H-pyrazol-4-yl)phenyl)amino)-5′,7′-dihydrospiro[pyrrolidine-3,6′-pyrrolo[2,3-d]pyrimidin]-2-one (C169);
• 7′-cyclopentyl-2′-((6-(2-(pyrrolidin-1-yl)ethoxy)pyridin-3-yl)amino)-5′,7′-dihydrospiro[pyrrolidine-3,6′-pyrrolo[2,3-d]pyrimidin]-2-one (C170);
• 7′-cyclopentyl-2′-((6-(2-(piperidin-1-yl)ethoxy)pyridin-3-yl)amino)-5′,7′-dihydrospiro[pyrrolidine-3,6′-pyrrolo[2,3-d]pyrimidin]-2-one (C171);
• 7′-cyclopentyl-2′-((4-((S)-3-(dimethylamino)pyrrolidin-1-yl)phenyl)amino)-5′,7′-dihydrospiro[pyrrolidine-3,6′-pyrrolo[2,3-d]pyrimidin]-2-one (C172);
• 7′-cyclopentyl-2′-((4-((S)-3-(dimethylamino)pyrrolidin-1-yl)-3-fluorophenyl)amino)-5′,7′-dihydrospiro[pyrrolidine-3,6′-pyrrolo[2,3-d]pyrimidin]-2-one (C173);
• 7′-cyclopentyl-2′-((6-((S)-3-(dimethylamino)pyrrolidin-1-yl)pyridin-3-yl)amino)-5′,7′-dihydrospiro[pyrrolidine-3,6′-pyrrolo[2,3-d]pyrimidin]-2-one (C174);
• 7′-cyclopentyl-2′-((4-((R)-3-(dimethylamino)pyrrolidin-1-yl)phenyl)amino)-5′,7′-dihydrospiro[pyrrolidine-3,6′-pyrrolo[2,3-d]pyrimidin]-2-one (C175);
• 7′-cyclopentyl-2′-((4-((R)-3-(dimethylamino)pyrrolidin-1-yl)-3-fluorophenyl)amino)-5′,7′-dihydrospiro[pyrrolidine-3,6′-pyrrolo[2,3-d]pyrimidin]-2-one (C176);
• 7′-cyclopentyl-2′-((6-((R)-3-(dimethylamino)pyrrolidin-1-yl)pyridin-3-yl)amino)-5′,7′-dihydrospiro[pyrrolidine-3,6′-pyrrolo[2,3-d]pyrimidin]-2-one (C177);
• 7′-cyclopentyl-2′-((4-((S)-3-(dimethylamino)pyrrolidine-1-carbonyl)phenyl)amino)-5′,7′-dihydrospiro[pyrrolidine-3,6′-pyrrolo[2,3-d]pyrimidin]-2-one (C178);
• 7′-cyclopentyl-2′-((4-((S)-3-(dimethylamino)pyrrolidine-1-carbonyl)-3-fluorophenyl)amino)-5′,7′-dihydrospiro[pyrrolidine-3,6′-pyrrolo[2,3-d]pyrimidin]-2-one (C179);
• 7′-cyclopentyl-2′-((6-((S)-3-(dimethylamino)pyrrolidine-1-carbonyl)pyridin-3-yl)amino)-5′,7′-dihydrospiro[pyrrolidine-3,6′-pyrrolo[2,3-d]pyrimidin]-2-one (C180);
• 7′-cyclopentyl-2′-((4-((R)-3-(dimethylamino)pyrrolidine-1-carbonyl)phenyl)amino)-5′,7′-dihydrospiro[pyrrolidine-3,6′-pyrrolo[2,3-d]pyrimidin]-2-one (C181);
• 7′-cyclopentyl-2′-((4-((R)-3-(dimethylamino)pyrrolidine-1-carbonyl)-3-fluorophenyl)amino)-5′,7′-dihydrospiro[pyrrolidine-3,6′-pyrrolo[2,3-d]pyrimidin]-2-one (C182);
• 7′-cyclopentyl-2′-((6-((R)-3-(dimethylamino)pyrrolidine-1-carbonyl)pyridin-3-yl)amino)-5′,7′-dihydrospiro[pyrrolidine-3,6′-pyrrolo[2,3-d]pyrimidin]-2-one (C183);
• 7′-cyclopentyl-2′-((4-isopropylphenyl)amino)-5′,7′-dihydrospiro[pyrrolidine-3,6′-pyrrolo[2,3-d]pyrimidin]-2-one (C184);
• 7′-cyclopentyl-2′-((3-fluoro-4-isopropylphenyl)amino)-5′,7′-dihydrospiro[pyrrolidine-3,6′-pyrrolo[2,3-d]pyrimidin]-2-one (C185);
• 2′-((4-acetyl-3-fluorophenyl)amino)-7′-cyclopentyl-5′,7′-dihydrospiro[pyrrolidine-3,6′-pyrrolo[2,3-d]pyrimidin]-2-one (C186);
• 2′-((4-(tert-butyl)-3-fluorophenyl)amino)-7′-cyclopentyl-5′,7′-dihydrospiro[pyrrolidine-3,6′-pyrrolo[2,3-d]pyrimidin]-2-one (C187);
• 7′-cyclopentyl-2′-((4-hydroxy-4-methylcyclohexyl)amino)-5′,7′-dihydrospiro[pyrrolidine-3,6′-pyrrolo[2,3-d]pyrimidin]-2-one (C188);
• 7′-cyclopentyl-2′-(((1s,4s)-4-hydroxy-4-methylcyclohexyl)amino)-5′,7′-dihydrospiro[pyrrolidine-3,6′-pyrrolo[2,3-d]pyrimidin]-2-one (C189);
• 7′-cyclopentyl-2′-(((1 r,4r)-4-hydroxy-4-methylcyclohexyl)amino)-5′,7′-dihydrospiro[pyrrolidine-3,6′-pyrrolo[2,3-d]pyrimidin]-2-one (C190);
• 7′-cyclopentyl-2′-((5-(2-(dimethylamino)ethoxy)pyridin-2-yl)amino)-5′,7′-dihydrospiro[pyrrolidine-3,6′-pyrrolo[2,3-d]pyrimidin]-2-one (C191);
• 7′-cyclopentyl-2′-((5-(2-(pyrrolidin-1-yl)ethoxy)pyridin-2-yl)amino)-5′,7′-dihydrospiro[pyrrolidine-3,6′-pyrrolo[2,3-d]pyrimidin]-2-one (C192);
• 7′-cyclopentyl-2′-((5-(2-(piperidin-1-yl)ethoxy)pyridin-2-yl)amino)-5′,7′-dihydrospiro[pyrrolidine-3,6′-pyrrolo[2,3-d]pyrimidin]-2-one (C193);
• (S)-7′-cyclopentyl-2′-(((1S,2S,4R)-1,7,7-trimethylbicyclo[2.2.1]heptan-2-yl)amino)-5′,7′-dihydrospiro[pyrrolidine-3,6′-pyrrolo[2,3-d]pyrimidin]-2-one (C194);
• (S)-7′-cyclopentyl-2′-(((1R,2S,4R)-1,7,7-trimethylbicyclo[2.2.1]heptan-2-yl)amino)-5′,7′-dihydrospiro[pyrrolidine-3,6′-pyrrolo[2,3-d]pyrimidin]-2-one (C195);
• (S)-7′-cyclopentyl-2′-(((1S,2S,3S,5R)-2,6,6-trimethylbicyclo[3.1.1]heptan-3-yl)amino)-5′,7′-dihydrospiro[pyrrolidine-3,6′-pyrrolo[2,3-d]pyrimidin]-2-one (C196);
• 7′-cyclopentyl-2′-((3-fluoro-4-(4-methylpiperazin-1-yl)phenyl)amino)-5′,7′-dihydrospiro[pyrrolidine-3,6′-pyrrolo[2,3-d]pyrimidin]-2-one (C197);
• 7′-cyclopentyl-2′-((3-fluoro-4-(4-methylpiperazin-1-yl)phenyl)amino)-5′,7′-dihydrospiro[pyrrolidine-3,6′-pyrrolo[2,3-d]pyrimidine]-2,5-dione (C198);
• 7′-cyclohexyl-2′-((4-(4-methylpiperazin-1-yl)phenyl)amino)-5′,7′-dihydrospiro[pyrrolidine-3,6′-pyrrolo[2,3-d]pyrimidin]-2-one (C199);
• 7′-cyclohexyl-2′-((3-fluoro-4-(4-methylpiperazin-1-yl)phenyl)amino)-5′,7′-dihydrospiro[pyrrolidine-3,6′-pyrrolo[2,3-d]pyrimidin]-2-one (C200);
• 7′-cyclohexyl-2′-((6-(4-methylpiperazin-1-yl)pyridin-3-yl)amino)-5′,7′-dihydrospiro[pyrrolidine-3,6′-pyrrolo[2,3-d]pyrimidin]-2-one (C201);
• 7′-cyclohexyl-2′-((5-(4-methylpiperazin-1-yl)pyridin-2-yl)amino)-5′,7′-dihydrospiro[pyrrolidine-3,6′-pyrrolo[2,3-d]pyrimidin]-2-one (C202);
• 7′-cyclopentyl-2′-((3-fluoro-4-(piperazin-1-yl)phenyl)amino)-5′,7′-dihydrospiro[pyrrolidine-3,6′-pyrrolo[2,3-d]pyrimidin]-2-one (C203);
• 7′-cyclopentyl-2′-((3-fluoro-4-(piperazin-1-yl)phenyl)amino)-5′,7′-dihydrospiro[pyrrolidine-3,6′-pyrrolo[2,3-d]pyrimidin]-2-one (C204);
• 7′-cyclopentyl-2′-((3-fluoro-4-(4-methylpiperazin-1-yl)phenyl)amino)-5′,7′-dihydrospiro[pyrrolidine-3,6′-pyrrolo[2,3-d]pyrimidin]-2-one (C205);
• 7′-cyclopentyl-2′-((3-fluoro-4-(4-methylpiperazin-1-yl)phenyl)amino)-5′,7′-dihydrospiro[pyrrolidine-3,6′-pyrrolo[2,3-d]pyrimidin]-2-one (C206);
• 7′-cyclopentyl-2′-((4-(3,5-dimethylpiperazin-1-yl)phenyl)amino)-5′,7′-dihydrospiro[pyrrolidine-3,6′-pyrrolo[2,3-d]pyrimidin]-2-one (C207);
• 7′-cyclopentyl-2′-((4-(3,5-dimethylpiperazin-1-yl)phenyl)amino)-5′,7′-dihydrospiro[pyrrolidine-3,6′-pyrrolo[2,3-d]pyrimidine]-2,5-dione (C208);
• 7′-cyclopentyl-2′-((4-isopropylphenyl)amino)-5′,7′-dihydrospiro[pyrrolidine-3,6′-pyrrolo[2,3-d]pyrimidin]-2-one (C209);
• 7′-cyclopentyl-2′-((5-(2-(dimethylamino)ethoxy)pyridin-2-yl)amino)-5′,7′-dihydrospiro[pyrrolidine-3,6′-pyrrolo[2,3-d]pyrimidin]-2-one (C210);
• tert-butyl(S)-7′-cyclopentyl-2′-(methylthio)-2-oxo-5′,7′-dihydrospiro[pyrrolidine-3,6′-pyrrolo[2,3-d]pyrimidine]-1-carboxylate (C211);
• tert-butyl(S)-7′-cyclohexyl-2′-(methylthio)-2-oxo-5′,7′-dihydrospiro[pyrrolidine-3,6′-pyrrolo[2,3-d]pyrimidine]-1-carboxylate (C212);
• or
• pharmaceutically acceptable salts thereof.