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US 2023/0065640 A1Published application
Combination therapies and biomarkers for treating b-cell lymphomas
OwnerXiang LI, Yiyou CHENinventors
Life of this patent
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Abstract
Provided are combination therapies and secondary biomarkers for treating MYCC-associated diffuse large B-cell lymphoma (DLBCL) with YM155-based therapies, and related kits, compositions, and methods of use thereof.
Claims49
A method for treating a MYCC-associated diffuse large B-cell lymphoma (DLBCL) in a subject in need thereof, comprising
- administering YM155 monobromide [1-(2-Methoxyethyl)-2-methyl-4,9-dioxo-3-(pyrazin-2-ylmethyl)-4,9-dihydro-1H-naphtho[2,3-d] imidazolium bromide], or an analog or derivative thereof,
- thereby treating the MYCC-associated DLBCL in the subject in need thereof.
A method for treating a MYCC/BCL2-associated diffuse large B-cell lymphoma (DLBCL) in a subject in need thereof, comprising
- administering YM155 monobromide [1-(2-Methoxyethyl)-2-methyl-4,9-dioxo-3-(pyrazin-2-ylmethyl)-4,9-dihydro-1H-naphtho[2,3-d] imidazolium bromide], or an analog or derivative thereof,
- thereby treating the MYCC/BCL2-associated DLBCL in the subject in need thereof.
A patient care kit, comprising:
- (a) means for measuring MYCC gene copy number, or MYCC gene chromosomal location site, in a diffuse large B-cell lymphoma (DLBCL) sample of tissue from a subject, including cancer tissue and non-cancerous tissue;
- (b) YM155 monobromide [1-(2-Methoxyethyl)-2-methyl-4,9-dioxo-3-(pyrazin-2-ylmethyl)-4,9-dihydro-1H-naphtho[2,3-d] imidazolium bromide], or an analog or derivative thereof;
- and
- (c) a second anti-cancer agent selected from CHOP (cyclophosphamide, doxorubicin, vincristine, and prednisone), an anti-CD20 antibody, bendamustine, a PARP inhibitor, and a BCL2 inhibitor, including combinations thereof, optionally R-CHOP (ritixumab+CHOP).
1 more element
A patient care kit, comprising:
- (a) means for measuring MYCC gene copy number, or MYCC gene chromosomal location site, in a diffuse large B-cell lymphoma (DLBCL) sample of tissue from a subject, including cancer tissue and non-cancerous tissue;
- (b) means for determining BCL2 expression in the DLBCL sample of tissue from the subject, and/or means for determining alterations of the BCL2 gene (18q21 locus) in the sample of tissue from the subject;
- and
- (c) YM155 monobromide [1-(2-Methoxyethyl)-2-methyl-4,9-dioxo-3-(pyrazin-2-ylmethyl)-4,9-dihydro-1H-naphtho[2,3-d] imidazolium bromide], or an analog or derivative thereof.
1 more element
Dependencies are inferred from the claim text.