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OwnerSusanne KOSSATZ, Thomas REINER +2inventors
InventorsSusanne KOSSATZ, Thomas REINER, Wolfgang WEBER, Snehal G. PATEL
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The present disclosure describes methods of use of a composition comprising PARPi-fl to be administered to the oral cavity (e.g., via topical application to surfaces of the oral cavity) followed by imaging of the oral cavity for detection of squamous cell carcinoma of the oral cavity (e.g., in vivo, e.g., in a dental office setting or intraoperatively). The results disclosed herein show that topically applied PARPi-fl and subsequent intraoperative imaging of oral cavities can improve surgical removal of squamous cell carcinoma cells compared to healthy cells.
-20. (canceled)
A method for intraoperative detection of a tumor, tumor margin, and/or residual tumor tissue during glioblastoma removal surgery, the method comprising the steps of:
The method of claim 1, wherein the fluorophore comprises a boron-dipyrromethane.
The method of claim 1, wherein the PARP1 inhibitor conjugated to a fluorophore is:
Dependencies are inferred from the claim text.