Polycyclic pyridopyrazine derivative
AssigneeShionogi & Co., Ltd.
InventorsYutaka TOMIDA, Takashi KAWASUJI
Life of this patent
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Abstract
The present invention provides a compound represented by the following Formula (I): wherein ring A is a C5-C7 non-aromatic carbocycle or a 5- to 7-membered non-aromatic heterocycle; ring B is a benzene ring or the like; Q is —NHC(O)— or a 5-membered aromatic heterocycle; R1 is each independently halogen or the like; R2a and R2b are each independently hydrogen, alkyl, or haloalkyl; R3 is alkyl or the like; R4 and R5 are each independently hydrogen or the like; R6 is each independently halogen, alkyl, haloalkyl, alkyloxy, haloalkyloxy, or alkyloxyalkyl; n is an integer of 1 to 3; and m is an integer of 0 to 3.
Claims20
A compound represented by Formula (I):
- wherein
- ring A is a C5-C7 non-aromatic carbocycle or a 5- to 7-membered non-aromatic heterocycle, and the non-aromatic carbocycle and the non-aromatic heterocycle may be further fused with a benzene ring, a 3- to 7-membered non-aromatic carbocycle, or a 3- to 7-membered non-aromatic heterocycle and may form a spiro ring of a 3- to 7-membered non-aromatic carbocycle and a 3- to 7-membered non-aromatic heterocycle;
- ring B is a benzene ring or a pyridine ring;
- Q is —NHC(O)— (the left bond binds to CR2aR2b) or a 5-membered aromatic heterocycle;
- R1 is each independently halogen, alkyl, haloalkyl, alkyloxy, cyano, or haloalkyloxy;
- R2a and R2b are each independently hydrogen, alkyl, or haloalkyl;
- R3 is alkyl or haloalkyl;
- R4 and R5 are each independently hydrogen or alkyl;
- R6 is each independently halogen, alkyl, haloalkyl, alkyloxy, haloalkyloxy, or alkyloxyalkyl;
- or
- two R6s bonded to a non-adjacent atom may be taken together with each other to form a C1-C3 bridge which may have an intervening heteroatom;
- n is an integer of 1 to 3;
- and
- m is an integer of 0 to 3,
- provided that, when m is 0, a) the ring B is a pyridine ring, b) the ring A is a C5-C7 non-aromatic carbocycle, the non-aromatic carbocycle may be further fused with a benzene ring, a 3- to 7-membered non-aromatic carbocycle, or a 3- to 7-membered non-aromatic heterocycle and may form a spiro ring of a 3- to 7-membered non-aromatic carbocycle and a 3- to 7-membered non-aromatic heterocycle, and Q is a 5-membered aromatic heterocycle, c) the ring A is a C5-C7 non-aromatic carbocycle, the non-aromatic carbocycle may be further fused with a benzene ring, a 3- to 7-membered non-aromatic carbocycle, or a 3- to 7-membered non-aromatic heterocycle and may form a spiro ring of a 3- to 7-membered non-aromatic carbocycle and a 3- to 7-membered non-aromatic heterocycle, Q is —NHC(O)—, and a group represented by the following formula
- or d) the ring A is a 5- to 7-membered non-aromatic heterocycle, the non-aromatic heterocycle may be further fused with a benzene ring, a 3- to 7-membered non-aromatic carbocycle or a 3- to 7-membered non-aromatic heterocycle and may form a spiro ring of a 3- to 7-membered non-aromatic carbocycle and a 3- to 7-membered non-aromatic heterocycle, Q is a 5-membered aromatic heterocycle, and a group represented by the following formula
- provided that the following compounds are excluded:
- or a pharmaceutically acceptable salt thereof.
A compound represented by Formula (IA):
- wherein
- ring A is a C5-C6 non-aromatic carbocycle;
- ring B is a benzene ring or a pyridine ring;
- Q is —NHC(O)— (the left bond binds to CR2aR2b) or a 5-membered aromatic heterocycle;
- R1 is each independently halogen, alkyl, haloalkyl, alkyloxy, cyano, or haloalkyloxy;
- R2a and Rab are each independently hydrogen, alkyl, or haloalkyl;
- R3 is alkyl or haloalkyl;
- R6 is each independently halogen, alkyl, haloalkyl, alkyloxy, haloalkyloxy, or alkyloxyalkyl;
- or
- two R6s bonded to a non-adjacent atom may be taken together with each other to form a C1-C3 bridge;
- n is an integer of 1 to 3;
- and
- m is an integer of 0 to 2,
- provided that the following compounds are excluded:
- or a pharmaceutically acceptable salt thereof.
Dependencies are inferred from the claim text.