Antibodies to MASP-2
AssigneeHelion Biotech ApS
InventorsFlemming Larsen, Ulla Wahlers
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Abstract
The invention relates to antibodies to MASP-2 and functional equivalents thereof. In particular, the invention relates to MASP-2 antibodies capable of inhibiting the function of MASP-2. The invention furthermore discloses MASP-2 epitopes, wherein antibodies recognizing said epitopes are in particularly useful for inhibiting MASP-2 activity. The invention also relates to methods of producing said antibodies, methods of inhibiting MASP-2 activity as well as to pharmaceutical compositions comprising the MASP-2 antibodies.
Claims10
An antibody or antigen binding fragment thereof specifically recognizing and binding a polypeptide fragment of human MASP-2-consisting of the CCP1, CCP2 and serine protease domains (aa 293 to 686 of SEQ ID 1) wherein the antibody, or antigen binding fragment thereof, is capable of inhibiting MASP-2 catalyzed C4 deposition
Dependencies are inferred from the claim text.