Medicinal compositions for carbon dioxide based metered dose inhalers

A pressurized medicinal composition comprising:

• a carrier fluid and at least one active pharmaceutical ingredient dissolved or suspended in the carrier fluid,
• wherein the carrier fluid comprises about 40% to about 98%, by weight, of a first component and about 2% to about 60%, by weight, of a second component mixed together in a homogeneous solution,
• wherein the first component is liquid carbon dioxide, and
• wherein the second component is liquid at room temperature and pressure.

A pressurized medicinal composition comprising:

• a carrier fluid and at least one active pharmaceutical ingredient dissolved or suspended in the carrier fluid,
• wherein the carrier fluid comprises about 40% to about 98%, by weight, of a first component and about 2% to about 60%, by weight, of a second component,
• wherein the first component is a propellant,
• wherein the second component is a non-propellant, and
• wherein the first, propellant component is liquid carbon dioxide.

A pressurized medicinal composition comprising:

• at least about 40%, by weight, of a first component that is liquid carbon dioxide,
• an amount of a second component that is a fluid that forms a homogeneous solution with the liquid carbon dioxide, and
• at least one active pharmaceutical ingredient dissolved or suspended in the composition,
• wherein the liquid to supercritical transition temperature of the composition is greater than about 40° C.